The study investigated the economics of cassava processing in Otukpo Local Government Area, Benue State, Nigeria. Data were collected using well-structured questionnaire administered to 60 cassava processors. Data collected were analyzed using descriptive statistics, Profit function, independent sample t-test and Analysis of Variance (ANOVA). Results showed that majority of the processors were within the age group of 31–40 years with mean year of experience of 34 years. They were mostly women with an average of 8 persons per household. Traditional technologies mostly were employed by the cassava processors. The profitability analysis showed that cassava processing into garri (fried cassava granules), chips and fufu/akpu (cassava dough) are profitable, (t =23.55, 11.95, 12.37: P≤ 0.01). Moreover, the result of the ANOVA showed that there was a significant difference (F=44.48:P≤0.01) in the profit level of cassava processed into garri, chips and fufu/akpu. The result of the post-hoc of ANOVA shows that among the three cassava products studied, garri had the highest profit. The cassava processors encountered many set-backs like poor equipment, high cost of transportation, inadequate capital and poor road network even though processing is a viable and profitable venture. Modern processing technologies should be developed and disseminated to processors while adequate infrastructural facilities and credits should also be provided.