Ischemic stroke is caused by blood clot formation and consequent vessel blockage. Proteomic approaches provide a cost-effective alternative to current diagnostic methods, including computerized tomography (CT) scans and magnetic resonance imaging (MRI). To identify diagnostic biomarkers associated with ischemic stroke risk factors, we performed individual proteomic analysis of serum taken from 20 healthy controls and 20 ischemic stroke patients. We then performed SWATH analysis, a data-independent method, to assess quantitative changes in protein expression between the two experimental conditions. Our analysis identified several candidate protein biomarkers, 11 of which were validated by multiple reaction monitoring (MRM) analysis as novel diagnostic biomarkers associated with ischemic stroke risk factors. Our study identifies new biomarkers associated with the risk factors and pathogenesis of ischemic stroke which, to the best of our knowledge, were previously unknown. These markers may be effective in not only the diagnosis but also the prevention and management of ischemic stroke.

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Accurate image quality assessment (IQA) is crucial to optimize computed tomography (CT) image protocols while keeping the radiation dose as low as reasonably achievable. In the medical domain, IQA is based on how well an image provides a useful and efficient presentation necessary for physicians to make a diagnosis. Moreover, IQA results should be consistent with radiologists’ opinions on image quality, which is accepted as the gold standard for medical IQA. As such, the goals of medical IQA are greatly different from those of natural IQA. In addition, the lack of pristine reference images or radiologists’ opinions in a real-time clinical environment makes IQA challenging. Thus, no-reference IQA (NR-IQA) is more desirable in clinical settings than full-reference IQA (FR-IQA). Leveraging an innovative self-supervised training strategy for object detection models by detecting virtually inserted objects with geometrically simple forms, we propose a novel NR-IQA method, named deep detector IQA (D2IQA), that can automatically calculate the quantitative quality of CT images. Extensive experimental evaluations on clinical and anthropomorphic phantom CT images demonstrate that our D2IQA is capable of robustly computing perceptual image quality as it varies according to relative dose levels. Moreover, when considering the correlation between the evaluation results of IQA metrics and radiologists’ quality scores, our D2IQA is marginally superior to other NR-IQA metrics and even shows performance competitive with FR-IQA metrics.

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