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ObjectiveAs one of the cancers that seriously threatens women’s health, ovarian cancer has a high morbidity and mortality rate. Surgery and chemotherapy are the basic treatment strategies for ovarian cancer, and chemotherapy resistance is a significant factor in affecting the prognosis, survival cycle, and recurrence of ovarian cancer. This article aims to analyze articles about ovarian cancer and drug resistance via bibliometric software, offering new ideas and directions for researchers in this field.MethodsBoth Citespace and Vosviewer are bibliometric software on the Java platform. Articles were collected on ovarian cancer and drug resistance in the Web of Science Core Collection database from 2013 to 2022. The countries, institutions, journals, authors, keywords, and references were analyzed, and the development status of this field was indicated from multiple perspectives.ResultsStudies on ovarian cancer and drug resistance generally showed an increasing trend from 2013 to 2022. The People’s Republic of China and Chinese institutions contributed more to this field. Gynecologic Oncology published the most articles, and the journal with the most citations was Cancer Research. Li Li was the author with the most publications, and Siegel RL was the author with the most citations. Through burst detection, it can be found that the research hotspots in this field mainly focused on the in-depth exploration of the drug resistance mechanism of ovarian cancer and the progress of PARP inhibitors and bevacizumab in the treatment of ovarian cancer.ConclusionsMany studies on the mechanism of drug resistance in ovarian cancer have been discovered; however, the deeper mechanism remains to be explored. Compared with traditional chemotherapy drugs, PARP inhibitors and bevacizumab have shown better efficacy, but PARP inhibitors have initially shown drug resistance. The future direction of this field should be to overcome the resistance of existing drugs and actively develop new ones.

Background; The primo vascular system (PVS) is new circulatory system. However, the primo vascular system doesn’t achieve now on the valuation criteria on the substance of meridians, so that anyone can't prove that the primo vascular system is the substance of meridians. Objectives: The purpose of this study is to prove clinical-physiologically that the primo vascular system is the substance of acupuncture meridian.Methods: Meridian-like high thermal line (MLHTL) induced by the mineral pulse light stimulus on acupoints, and nephrotic syndrome treated simultaneously without any drug use, were researched and analyzed. Next, the inducing characteristic of meridian-like high thermal lines and, anatomic and electro-physiologic characteristic of PVS were researched and analyzed. Results: The KI, SP meridian-like high thermal line coinciding completely along the classic KI, SP meridian course, were induced by the mineral pulse light stimulus on SP6 acupoints, and simultaneously nephrotic syndrome in kidney, the internal target organ connected along KI meridian from the KI3, SP6 acupoints, was treated without any drug use. And the primo vascular system was basis tissue of MLHTL inducing. Conclusions: The primo vascular system was achieved completely to the valuation criteria on the substance of meridians. Thus, the primo vascular system is the substance of meridians.

Background; Hepatocellular carcinoma (HCC) represents a major and steadily increasing global health challenge as the most common primary liver malignancy and leading cause of death in cirrhotic patients. The only hope for curative treatment or significant increase in life expectancy is early detection. Once patients have progressed towards end-stage HCC, effective treatment options are extremely limited on the background of a very high degree of heterogeneity in clinical presentation and outcome. Objectives; The purpose of this study is to perform clinical trial on an end-stage HCC patient by mineral pulse light stimulus on LV acupoints without any drugs use. Methods; End-stage HCC patient was stimulated by mineral pulse light stimulator (MPLS). Stimulus acupoints; LV3, LV14, SP6. The selected acupoints were stimulated by MPLS for 50~60 minutes once a day. The same method was performed on the patient for 25days and rested for 5days, and again repeated every month without any drugs use. Results; After treatment, the general patient conditions and alfa-fetoprotein level were improved and hepatoma size was decreased to 9.1×8.5cm from 11.0×9.7cm before treatment (a), and the decay areas was disappeared.Conclusions; End-stage HCC patient was improved by mineral pulse light stimulus on LV acupoints without any drugs use.

Background; The acupuncture meridian is the channel through which Qi & Blood flow, and acupuncture is having many thousands year history for treating various illnesses. However, there was no powerful evidence to prove the existence of meridians until now. Objectives; The purpose of this study is to explain that the meridian-like high thermal line (MLHTL) is the powerful evidence to prove the existence of meridians in human body. Methods; The meridian-like high thermal line inducing and the disease cure effect in the target organs connected along the meridians by the mineral pulse light stimuli, was researched and analyzed. Results; The meridian-like high thermal lines were induced along the classic meridians course at the human body surface, and simultaneously the internal refractory diseases such as nephrotic syndrome and angina pectoris were treated in the target organs connected along the meridians without drug use by the mineral pulse light stimuli. Conclusions; The meridian-like high thermal line is the powerful evidence to prove the existence of meridians in human body. From now on, MPL stimulator (Version 1) can induce MLHTL, and can show the non-drug cure effect in target organ connected along MLHTL.