PAF, which is composed of Paf1, Cdc73, Ctr9, Leo1, and Rtf1, is a novel complex with multiple functions in transcription-related activities. The PAF complex interacts with histone-modifying enzymes and RNA polymerase II to regulate transcription. With general transcription regulatory potential in yeast, Hyrax/ Cdc73 has been reported to associate with ␤-catenin to control Wnt/Wg signal-specific transcription in Drosophila. Here, we present the first evidence of IL-6 signal-specific transcriptional regulation by SH2BP1/CTR9 in mammals. Upon LPS injection of mice, we observed transient induction of the mammalian PAF complex in the liver. Inhibition of CTR9 specifically abrogated expression of IL-6-responsive genes, but had no effect on genes constitutively expressed or induced by interferon-␤, TNF␣, or IL-1␤. The PAF complex was found in the promoter regions of IL-6-responsive HP and FGG␥, but not in the promoter region of constitutively active GAPDH. Transcriptional activation by STAT3 was inhibited when CTR9 siRNA was introduced, whereas transcriptional activation was enhanced by mCtr9 overexpression. IL-6-activated Stat3 was found to co-localize and interact with CTR9. In CTR9-depleted cells, decreased STAT3 association with the promoter regions, as well as impaired K4-trimethylation of histone H3 in the coding regions, of target genes was observed. These data suggest that CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation.

Nonvacuum and photolithography-free copper (Cu) films were prepared by reverse offset printing. The mechanical, morphological, structural, and chemical properties of the Cu films annealed at different temperatures were examined in detail. The Ostwald ripening-induced coalescence and grain growth in the printing Cu films were enhanced with increasing annealing temperature in N2 ambient up to 400 °C. Simultaneously, unwanted chemical impurities such as oxygen, hydrogen, and carbon in the Cu films decreased as the annealing temperature increased. The high electrical conductivity (∼6.2 μΩ·cm) of the printing Cu films annealed at 400 °C is attributed to the enlargement of the grain size and reduction of the incorporation of impurities. A printing Cu film was adopted as a source/drain (S/D) electrode in solution processable zinc tin oxide (ZTO) field-effect transistors (FETs), where the ZTO film was prepared by simple spin-coating. The ZTO FETs fabricated at a contact annealing temperature of 250 °C exhibited a promising field-effect mobility of 2.6 cm(2)/(V s), a threshold voltage of 7.0 V, and an ION/OFF modulation ratio of 2 × 10(5).

Recently, the interest on applying AVM(Around View Monitoring) systems in construction equipments have been increasing due to the demand for better control, work efficiency and safety. Most of the existing AVM systems have been developed focusing on the application in automobiles and only several AVM systems have been developed for construction equipments. However, the original technology of AVM remained the same as in the automobiles that failed to consider the main properties of construction equipments and suggest appropriate range of AVM display (Top-view). Therefore, the purpose of this study is to suggest a pilot type of AVM system for construction equipment. Accordingly, literature review, deduction of main consideration factors, selection of sensors, system design, algorithm development of a pilot type of AVM system for construction equipment have been conducted. A laboratory experiment has also been conducted for the deduction of further improvements. As a result, a minimum image refresh rate of 20 fps has been achieved that clearly reflects the actual situation of the equipment and also, the actual motions of Boom, Arm, Bucket have been displayed appropriately on the AVM system based on the angle data collected by sensors. However, the experiment results have also shown that the following tasks still remain for future work: 1)Improvement of AVM image interpolation, 2)Development of calibration module for variety construction equipment.

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ABSTRACT:The intelligent excavating system (IES) aims for the full-scale automation of the excavation process that includes a series of tasks such as movement, excavation, and loading. The core elements of the IES include excavating robots, 3D modeling of surrounding terrains, and the technology for detecting objects accurately (i.e., for detecting the location of nearby loading trucks and humans as well as of obstacles positioned on the movement paths). These are absolutely necessary in ensuring the performance quality and safety of the equipment. This study was conducted to detect the terrains and objects near the location of the intelligent excavating robot via a 3D laser scanning system and to ensure the quality and safety of automated excavation. Moreover, an algorithm for estimating the location, height, width, and shape of objects in the 3D-realized terrain that surrounds the location of the excavator was proposed. The performance of the algorithm was verified via tests inside an actual earthwork field.