The PICES CCCC (North Pacific Marine Science Organization, ClimateChange and Carrying Capacity program) MODEL Task Team achieved a consensus on the structure of a prototype lower trophic level ecosystem model for the North Pacific Ocean, and named it the North Pacific Ecosystem Model for Understanding Regional Oceanography, "NEMURO". Through an extensive dialog between modelers, plankton biologists and oceanographers, an extensive review was conducted to define NEMURO's process equations and their parameter values for distinct geographic regions. We present in this paper the formulation, structure and governing equations of NEMURO as well as examples to illustrate its behavior. NEMURO has eleven state variables: nitrate, ammonium, small and large phytoplankton biomass, small, large and predatory zooplankton biomass, particulate and dissolved organic nitrogen, particulate silica, and silicic acid concentration. Several applications reported in this issue of Ecological Modelling have successfully used NEMURO, and an extension that includes fish as an additional state variable. Applications include studies of the biogeochemistry of the North Pacific, and variations of its ecosystem's lower trophic levels and two target fish species at regional and basin-scale levels, and on time scales from seasonal to interdecadal.5

We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4-11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.

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Diffusion of CsA across the sclera from the episcleral space was not a feasible method of drug delivery to the equine eye. However, placing a deep scleral lamellar CsA implant adjacent to the suprachoroidal space was effective in achieving therapeutic ocular drug concentrations and controlling uveitis in horses with ERU.

Fiber-based wearable displays, one of the most desirable requisites of electronic textiles (e-textiles), have emerged as a technology for their capability to revolutionize textile and fashion industries in collaboration with the state-of-the-art electronics. Nonetheless, challenges remain for the fibertronic approaches, because fiber-based light-emitting devices suffer from much lower performance than those fabricated on planar substrates. Here, we report weavable and highly efficient fiber-based organic light-emitting diodes (fiber OLEDs) based on a simple, cost-effective and low-temperature solution process. The values obtained for the fiber OLEDs, including efficiency and lifetime, are similar to that of conventional glass-based counterparts, which means that these state-of-the-art, highly efficient solution processed planar OLEDs can be applied to cylindrical shaped fibers without a reduction in performance. The fiber OLEDs withstand tensile strain up to 4.3% at a radius of 3.5 mm and are verified to be weavable into textiles and knitted clothes by hand-weaving demonstrations. Furthermore, to ensure the scalability of the proposed scheme fiber OLEDs with several diameters of 300, 220, 120, and 90 μm, thinner than a human hair, are demonstrated successfully. We believe that this approach, suitable for cost-effective reel-to-reel production, can realize low-cost commercially feasible fiber-based wearable displays in the future.