Background Being diagnosed with cancer during childhood or adolescence can disrupt important periods in an individual’s physical, psychosocial, and spiritual development and potentially reduce the quality of life (QOL) after treatment. Research is urgently required to improve the QOL for child and adolescent cancer survivors, and it is necessary to analyze the trends in prior research reported in international academic journals to identify knowledge structures. Objective This study aims to identify the main keywords based on network centrality, subgroups (clusters) of keyword networks by using a cohesion analysis method, and the main theme of child and adolescent cancer survivor–related research abstracts through topic modeling. This study also aims to label the subgroups by comparing the results of the cohesion and topic modeling. Methods A text network analysis method and topic modeling were used to explore the main trends in child and adolescent cancer survivor research by structuring a network of keyword (semantic morphemes) co-occurrence in the abstracts of articles published in 5 major web-based databases from 2016 to 2020. A total of 1677 child and adolescent cancer survivor–related studies were used for data analyses. Data selection, processing, and analyses were also conducted. Results The top 5 keywords in terms of degree and eigenvector centrality were risk, control interval, radiation, childhood cancer treatment, and diagnosis. Of the 1677 studies used for data analyses, cluster 1 included 780 (46.51%) documents under risk management, cluster 2 contained 557 (33.21%) articles under health-related QOL and supportive care, and cluster 3 consisted of 340 (20.27%) studies under cancer treatment and complications. Conclusions This study is significant in that it confirms the knowledge structure based on the main keywords and cross-disciplinary trends in child and adolescent cancer survivor research published in the last 5 years worldwide. The primary goal of child and adolescent cancer survivor research is to prevent and manage the various aspects of the problems encountered during the transition to a normal life and to improve the overall QOL. To this end, it is necessary to further revitalize the study of the multidisciplinary team approach for the promotion of age-specific health behaviors and the development of intervention strategies with increased feasibility for child and adolescent cancer survivors.

BACKGROUND Childhood and adolescent cancer survivors (CACS) face a high risk for experiencing physical and psychological problems after the completion of their treatment. Effective healthy lifestyle interventions and strategies to improve their health-related quality of life are needed to prevent these problems. TherefThe object of this study was to investigate the effect of healthy lifestyle intervention study to improve the health-related quality of life in children and adolescent cancer survivors.ore, it should be preceded by verifying the effectiveness of various existing studies on the healthy lifestyle interventions of CACS. OBJECTIVE The object of this study was to investigate the effect of healthy lifestyle intervention study to improve the health-related quality of life in children and adolescent cancer survivors. METHODS MEDLINE via PubMed, Embase, PsycINFO, Cochrane Library, Web of Science, CINAHL, and several Korean web-based databases were searched for English written original articles published between January 1, 2000, and May 2, 2021. Randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) were included. Each individual study was assessed independently by two authors for quality assessment using the revised Cochrane risk-of-bias tool (RoB 2) for randomized trials and the ROBINS-I for non-randomized studies. Meta-analysis was conducted using RevMan 5.3 software. RESULTS A total of 19 studies were included in this study. Quality of life was significant when interventions were given as a mixed approach (exercise and education) (d = -0.46, 95% CI [-0.84,-0.07], P = 0.02), not less than six months (d = -0.72, 95% CI [-1.15,-0.29], P = 0.0010), group approach (d = -0.46, 95% CI [-0.85,-0.06], P = 0.02). Self-efficacy, one of the psychosocial outcomes, showed significant effect when interventions were provided with health education only (d = -0.55, 95% CI [-0.92,-0.18], P = 0.003), less than six months (d = -0.40, 95% CI [-0.69,-0.11], P = 0.006) and individually (d = -0.55, 95% CI [-0.92,-0.18], P = 0.003). The physical outcomes (physical activity, fatigue, exercise capacity-VO2, exercise capacity-upper body, BMI) revealed no statistical significance CONCLUSIONS The area of healthy lifestyle interventions (HLSIs) of CACS that have not yet been actively studied were identified, and the need and direction of research for holistic health management could be suggested. CLINICALTRIAL NA

BACKGROUND Being diagnosed with cancer during childhood or adolescence can disrupt important periods in an individual’s physical, psychosocial, and spiritual development and potentially reduce the quality of life (QOL) after treatment. Research is urgently required to improve the QOL for child and adolescent cancer survivors, and it is necessary to analyze the trends in prior research reported in international academic journals to identify knowledge structures. OBJECTIVE This study aims to identify the main keywords based on network centrality, subgroups (clusters) of keyword networks by using a cohesion analysis method, and the main theme of child and adolescent cancer survivor–related research abstracts through topic modeling. This study also aims to label the subgroups by comparing the results of the cohesion and topic modeling. METHODS A text network analysis method and topic modeling were used to explore the main trends in child and adolescent cancer survivor research by structuring a network of keyword (semantic morphemes) co-occurrence in the abstracts of articles published in 5 major web-based databases from 2016 to 2020. A total of 1677 child and adolescent cancer survivor–related studies were used for data analyses. Data selection, processing, and analyses were also conducted. RESULTS The top 5 keywords in terms of degree and eigenvector centrality were <i>risk</i>, <i>control interval</i>, <i>radiation</i>, <i>childhood cancer treatment</i>, and <i>diagnosis</i>. Of the 1677 studies used for data analyses, cluster 1 included 780 (46.51%) documents under <i>risk management</i>, cluster 2 contained 557 (33.21%) articles under <i>health-related QOL and supportive care</i>, and cluster 3 consisted of 340 (20.27%) studies under <i>cancer treatment</i> and <i>complications</i>. CONCLUSIONS This study is significant in that it confirms the knowledge structure based on the main keywords and cross-disciplinary trends in child and adolescent cancer survivor research published in the last 5 years worldwide. The primary goal of child and adolescent cancer survivor research is to prevent and manage the various aspects of the problems encountered during the transition to a normal life and to improve the overall QOL. To this end, it is necessary to further revitalize the study of the multidisciplinary team approach for the promotion of age-specific health behaviors and the development of intervention strategies with increased feasibility for child and adolescent cancer survivors. CLINICALTRIAL