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Within the framework of the educational and research project "Real Clinical Practice of Treatment of Acid-Dependent Diseases", H. pylori-associated pathology and their dynamics after the eradication the nature and severity of clinical manifestations were evaluated. In the analysis 1,474 patients were included aged 18 to 87 years old (average age 45.7 years) with confirmed H. pylori infection, who were observed on an outpatient basis in 188 doctors in Moscow, the Moscow Region and St. Petersburg. Diagnosis of H. pylori and subsequent eradication control were carried out with the use of methods available in real clinical practice. The severity of symptoms was assessed using “7×7” Questionnaire (seven symptoms for seven days). On the first visit, the average score was 12.5, on the second 4.5, and on the third 1.7 points. The significant relationship between smoking and the severity of dyspeptic manifestations was revealed. Rabeprazole was the most commonly prescribed proton pump inhibitor (84.3%) in the eradication regimens.

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Human intestinal microbiota is an evolutionary set of microorganisms that exists as a balanced microecological system providing homeostasis of the macroorganism necessary for maintaining health. Changes in the intestinal microbiota can contribute to the occurrence of various gastrointestinal disorders, including constipation syndrome. The intestinal microbiota is one of the main moderators of the association between the intestine and the nervous system, taking an active part in the neuroendocrine regulation of motor skills. Сlinical study results indicated the presence of specific changes in the intestinal microbiota in chronic constipation and demonstrated the possibility of using probiotics for intestinal transit time correlation. The main representative of the human normal flora are microorganisms of the Bifidobacterium genus, which quantitative or specific changes are observed in various intestinal and extra-intestinal diseases. Many of the intestinal microbiota effects are strain-specific, suggesting the potential role of certain probiotic strains as possible adjuvant drugs for targeted therapy. This review aims at providing the most complete information on the action mechanisms of the gastrointestinal microbiota (in particular representatives of the Bifidobacterium genus) on the intestinal motor function and therapeutic possibilities of probiotic strains in the targeted correlation of delayed intestinal transit. KEYWORDS: intestinal microbiota, constipation, probiotics, Bifidobacteria, homeostasis, intestinal motility. FOR CITATION: Oganezova I.A., Medvedeva O.I. Changes in intestinal microbiota as a cause and potential therapeutic target in constipation syndrome. Russian Medical Review. 2020;4(5):302–307. DOI: 10.32364/2587-6821-2020-4-5-302-307.