The precursors and hybrid compounds, including photochromic fulgimides and fluorescent benzothiazolylthienothiophene units, have been synthesized. Spectroscopic investigations by absorption and fluorescence methods showed that fulgimide hybrids display photochromism, but do not display fluorescence properties. A possible explanation for this fact is proposed and also the decreased effectiveness of photochromic conversion.Currently photochromic materials are actively under consideration as potential recording media for three-dimensional storage [1]. Important properties which determine their utility for these uses are nondestructive sensing of optical information, which is possible only in those cases when the sensed irradiation is not absorbed by two forms of photochromic compounds mutually transformed under the influence of light. One of the most fruitful routes for the solution of this problem is the creation of photochromic materials capable of sensing optical information by the fluorescence method [2,3]. For this objective in particular hybrid photochromic compounds were synthesized which contained in their structure both photochromic and fluorophoric units [4][5][6][7][8][9] in which the absorption bands of the fluorescent part of the molecule were located in addition to the adsorption bands of the two forms of the photochromic part, but the fluorescent spectrum coincides with the absorption spectrum of one of the forms of the photochromic compound.In the present work an attempt was made to synthesize new hybrid compounds based on photochromic amino-substituted fulgimides and fluorescent derivatives of benzothiazolylthienothiophene.

Measurements were made of plasma levels of free (f) thyroxine (fT4), triiodothyronine (fT3), thyrotropic hormone (TSH), adrenocorticotrophic hormone (ACTH), aldosterone, and renin in patients with dyscirculatory encephalopathy (DE). Their influences on the development of chronic circulatory insufficiency were assessed. A total of 39 patients were studied (aged 45-73 years) with DE stages I and II, without acute or chronic (in the exacerbation phase) somatic illness. These observations showed that diffuse lesions of brain tissues of different severities were accompanied by the following changes in thyroid homeostasis: 1) significant combined increases in TSH without alteration to the "fT3-TSH" negative feedback regulatory mechanism in patients with stage I DE; 2) significant combined decreases in TSH levels with marked suppression of the conversion of thyroxine into triiodothyronine and an interaction with impairments in the "fT3-hypophysis" system in patients with stage II DE. In addition, there were changes (increases) in cortisol levels with simultaneous decreases in renin levels in patients with stage II DE as compared with patients with stage I DE. Correlation analysis demonstrated the absence of any relationship between the age of the patients, the state of hormonal homeostasis, and the extent of vascular stenosis. These results suggest a role for hormones of the hypothalamo-hypophyseal-adrenal, thyroid, and renin-angiotensin systems in the mechanism by which DE develops as well as the possibility of using tests for these hormones as additional criteria for assessing the severity of diffuse brain lesions.

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