The aim of this study was to study the ultrasound characteristics of the pelvic organs and the characteristics of uterine blood flow in adolescents with abnormal uterine bleeding during puberty.Methods: Investigate 93 adolescent girls with abnormal uterine bleeding during puberty (AUBDP), aged 11 to 18 years (mean age was 14.5 ± 3.5 years). Patients with AUBDP were divided into 2 clinical groups: I group consisted of 44 patients 11-14 years old, group II -49 adolescent girls 15-17 years old. The control group included 25 person of the same age without menstrual disorders. The frequency of relapses of AMKPP in group I was 20,4%, in group II -28,5%.Ultrasound and Doppler study was performed using an ultrasound scanner "Siemens" (Germany), using a transabdominal sensor (3.5 MHz) and a transvaginal sensor (6.5-7 MHz) in adolescents who have sex.The conditional of blood flow in the uterine and spiral arteries was performed using Doppler study. The indices of vascular resistance in both the uterine and spiral arteries, the index resistance (IR), the pulsation index (PI), and the systolic-diastolic ratio (S/D) were calculated.Results: The study revealed hemodynamic changes in blood flow in girls with AUBDP. In this connection, the described changes in the parameters of blood flow in a. uterinae and a. radialis can serve as an additional diagnostic criterion for determining the risk of uterine bleeding during puberty. Conclusion:Based on the study, ultrasound and Dopplerometric features of the pelvic organs in adolescent girls with AUBDP were found, which were characterized by an increase in the size of the uterus, heterogeneous endometrial echostructure, an increase in the size of the ovaries, an increase in systolic and diastolic blood flow rates, and vascular resistance indices in a. uterinae and a.

Objectives: to determine the features of the uterine cavity in women with extragenital disorders and abnormal uterine bleedings (AUB) using modern diagnostic methods.Materials and methods. The study involved 100 women with AUB and concomitant extragenital disorders, who constituted the main group. The control group consisted of 50 somatically healthy women. Women underwent ultrasound with Doppler mapping, and MRI if indicated to assess the condition of the pelvic organs. Due to the presence of AUB the patients of the main group underwent hysteroscopy and/or separate diagnostic curettage with further morphological assessment of the material obtained.Results. Ultrasound showed that the uterine size in women of the control group corresponded to physiological norms, and the thickness and structure corresponded to the M-echo phase of the menstrual cycle. The main group was additionally divided into subgroups depending on the detected pathological changes in the uterine cavity: endometrial polyp (glandular polyp, adenofibromatous polyp), submucous leiomatous node, endometrial polyp and submucous leiomatous node, endometrial hyperplasia, endometrial hyperplasia in combination with submucous leiomatous node. During the Doppler study the blood flow in the uterine, basal and spiral arteries was analyzed depending on the echographic assessment of the state of the uterine cavity in the main group in comparison with the data of the control group. The patients of the main group were found to have a significant increase in the level of the pulsation index in all the studied vessels in comparison with the corresponding values in the control group (Kruskal–Wallis test, Mann–Whitney test, p < 0.001).Conclusions. The most common disorder of the uterine cavity in women with extragenital diseases and AUB, detected by ultrasound scanning, were polyps of the uterine cavity and endometrial hyperplasia. A feature of blood flow in pathological processes in the uterine cavity was an increase in the pulsation index in the uterine, basal and spiral arteries in women of the main group compared to the control group.

Electronic poster abstractsMethods: A total of 657 women with16 weeks -41 weeks of normal gestation were enrolled in the study who received routine obstetric ultrasound in our hospital from September 2008 to March 2015. The volume and blood flow parameters of kidney and fetal growth parameters were measured by two and three dimensional ultrasound. The relations between various parameters of kidney with gestational age, growth indexes were analysed. Results: Renal volume was linearly associated with gestational age, and renal volume = -7.01 + 0.554 × gestational age (16 weeks≤ gestational age≤ 41 weeks).Fetal volume was significantly related to growth indexes, and the correlation with height, weight before pregnancy was not obvious.PSV, EDV and TAMXV of renal artery increased with gestational age; S/D, PI and RI decreased with gestational age. Conclusions: The volume of normal fetal kidney increases gradually along with the gestational age, a linear correlation is between them.The size of normal fetal kidney is associated with fetal growth itself, but is not affected by maternal height, weight before pregnancy. With the increase of gestational age, the blood flow of fetal renal artery speeds, resistance drops and blood flow perfusion increases. Objectives: Evidence suggests that an adverse environment during intrauterine life and early childhood is a risk factor for a wide spectrum of disorders later in life, including cardiovascular and renal disease. We aim to evaluate the role of intrauterine growth restriction in kidney disease in adulthood. Methods: An electronic search was conducted through October 2016 in the CENTRAL, LILACS, MEDLINE, and EMBASE databases. The inclusion criteria were studies comparing renal function in adulthood with birth weight using transversal or longitudinal designs. The reviewers analysed the inclusion criteria and risk bias and extracted data from the included studies. Twenty articles met the inclusion criteria for the systematic review, and 13 were included in the meta-analysis. Results: There was an increased risk of developing end-stage renal disease (risk ratio (RR) 1.31, 95% confidence interval (CI): 1.17, 1.47), a lower glomerular filtration rate (ml/min) (mean difference (MD) -7.14; 95% CI: -12.12, -2.16), microalbuminuria (RR 1.40; 95% CI: 1.28, 1.52) and a small increase in the albumin/creatinine ratio (MD 0.46; 95% CI: 0.03, 0.90) in the low birth weight group. Conclusions: Our results suggest that low birth weight is related to renal dysfunction in adulthood. Objectives: Although an absent or reversed a-wave in ductus venosus (DV-RAV) is reported to be the terminal finding of fetal growth restriction (FGR), we have seen a DV-RAV that disappears in a short span of time, causing us to reconsider the mechanism of DV-RAV in FGR. EP14.08Methods: This was a retrospective study of 499 FGR cases, including 14 with DV-RAV. Transabdominal amnioinfusion (AI) was performed when oligohydramnios was severe and/or a sign of cord compression was detected. DV-RAV that disappeared in a sho...

External genital endometriosis is one of the most common gynecological proliferative diseases. The disease development is based on molecular and genetic disorders that occur in women and are the result of the cell response to oxidative stress. In endometriosis the polymorphism of genes of detoxification systems, depletion of antioxidant defense mechanisms due to hormonal imbalance and activity of pro−inflammatory processes are called the causes of oxidative stress. Currently, much attention is paid to aspects of the immune system and local peritoneal factors. To develop diagnostic criteria for the stages of external genital endometriosis by determining the activity of enzymes of the antioxidant system and catalase in serum and peritoneal fluid, a study was performed in 86 patients. The research results showed that in external genital endometriosis of stages I−II in the serum of women the catalase activity increased, and that of superoxide dismutase remained at the physiological level. Determination of the studied enzymes in peritoneal fluid indicates that their parameters correspond to the control values in women without endometriosis. Thus, the study showed that the patients experience multidirectional changes in antioxidant system, which are manifested in increased catalase activity at the systemic level at the disease stages I−II and local one at stages III−IV. At the same time, the activity of superoxide dismutases at all stages of the disease in both serum and peritoneal fluid is normal. The state of the antioxidant system is concluded to depend on the peculiarities of micronutrient metabolism. Further study and correction of its possible disorders may positively affect in preventing and treatment of external genital endometriosis in women. Key words: external genital endometriosis, antioxidant system, diagnostics.

Study objective: to determine the clinical and diagnostic features of the abnormal uterine bleeding (AUB) in women of reproductive age with extragenital pathology.Materials and methods. The study involved a retrospective assessment of 400 case histories of reproductive aged women with AUB who underwent inpatient treatment.The main clinical group (I) consisted of 300 case histories of women with AUB and concomitant extragenital disorders, control group (II) consisted of 100 case histories of somatically healthy women with AUB. An ultrasound scan with Doppler mapping was performed to assess the pelvic organs. All women underwent hysteroscopy and/or separate diagnostic curettage with further morphological assessment of the endometrium.Results. The most common extragenital disorder was diseases of the circulatory system and endocrine system, diseases of the digestive system. 123 patients (41%) had concomitant hypertension and obesity, 76 (25.3%) – obesity and varicose veins, 53 (17.6%) – somatoform autonomic dysfunction and chronic gastritis, 39 (13%) – obesity and diabetes mellitus, 24 (8%) – chronic gastritis and obesity. AUB was complicated by anemia of varying severity in 176 (58.6%) women. According to ultrasound data the most common endometrial disorder in women of group I was glandular hyperplasia of the endometrium.Conclusion. A retrospective analysis of case histories showed a high prevalence of AUB among women with extragenital pathology, which is a clinical indicator of major menstrual disorders in this category of patients and can be a serious problem for women's health in general. The need to study the prevalence and identify the main risk factors for the AUB development will make it possible to provide a general strategy for its prevention, improve the reproductive potential of women and avoid serious abnormal changes in the process of fulfilment of the reproductive function in young women.