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Two different synthetic routes to 5‐(3,6‐dihydro‐2‐oxo‐2H‐1,3,4‐thiadiazin‐5‐yl)‐1H‐indole‐2,3‐diones are described. The reaction sequences represent a facile entry into these series of isatin derivatives.

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Stereospecificity of Myofibrillar Calcium Sensitivity and PDE Inhibition in Cardiotonic Thiadiazinones.-Enantiomers of the title compounds (V)-(VII) are prepared by stereoselective synthesis, cf. (R)-(+)-(V), or by standard resolution procedures using (-)-menthyl chloroformate or a chiral hydrazine derivative. In the thiadiazine series the (R)-configuration is essential for the Ca-sensitizing effect whereas the (S)-configuration supports the highest inhibition of PDE (phosphodiesterase) activity.-(NADLER, G.; DELIMOGE, I.; LAHOURATATE, P.; LEGER, I.; MORVAN, M.; ZIM-MERMANN, R. G.; Eur.