Pre-gestational diabetes in women with cystic fibrosis is associated with a higher rate of cesarean section but does not seem to have a clinically significant impact on fetal growth or preterm delivery. The changes in maternal pulmonary and nutritional status following pregnancy in women with cystic fibrosis were not influenced by pre-gestational diabetes.

Twenty nine cases of central nervous system infection due to Monosporium apiospermum have been reported. Six of them occurred after an aspiration pneumonia following a near drowning. The case of a 53 year old man is reported: M apiospermum was isolated from cerebrospinal fluid, sputum, urine and from the mud of the ditch where the patient had fallen. Though the treatment used recommended doses of intravenous, intrathecal and intraventricular amphotericin B, it was ineffective and the patient died 97 days after the near drowning. Necropsy showed that the ventricular infectious process was more prominent distant from the antifungal ventricular source. frontal headache and mild neck stiffness appeared while the remaining neurological examination was normal. CSF was clear with normal pressure and contained 280 leukocytes/mm3 (76% polymorphonuclear), 180 mg/dl proteins and 29 mg/dl glucose; CSF cultures were sterile. Brain CT scan revealed a left cerebellar lesion suggesting an abscess. Staphylococcus dermatitis was isolated from the blood cultures and catheter, and the patient was .treated with rifampicin (1800 mg IV daily), vancomycin (1500 mg IV daily) and ornidazole (1 g IV daily). Hydrocortisone (50 mg) and chloramphenicol (50 mg) were administered intrathecally every three days.The temperature fell to 37°C within three days but the patient remained confused. Thrombocytopaenia (75,000 platelets/mm3) was seen between day 47-50, and on the fifty first day, transient macular rashes appeared on

The case history is presented of a patient which illustrates both the diagnostic difficulties of an extremely rare tumour (choriocarcinoma of the lung) and its associated haemorrhagic metastases ("choriocarcinoma syndrome").