The professional stress is a physical and emotional harmful reaction. In fact, it presents a major public health problem in Morocco. Our work is directed to study the differences between the various groups of professional and nonprofessional drivers in terms of stress reactions, noise nuisance and implication in the production accidents. The present study is transversal descriptive type based on a questionnaire and neuropsychological tests conducted by 60 nonprofessional drivers and 60 taxi drivers in Kenitra. Two scales evaluated the stress: the Resistance Test of Stress (TRS) and the Perceived Stress Scale (PSS). According to this last scale, 63.5% of the taxi drivers were considered as stressed. These drivers have the following specific components: mood trouble, sleep trouble, pressure of time, work boredom, stress sensation and tiredness at the end of driving. 65% of drivers take a pause after 5 to 6 hours of work. According to the Test of Resistance at the Stress, the taxi driver's populations are more homogeneous but are less likely to resist stress compared to their nonprofessionals counterparts. Indeed to work on the professional stress requires a qualitative and quantitative approach phenomenon allowing a more complete vision. This study sheds new light on the understanding of stress at work by using new measurement and evaluation methods such as TRS, with an aim to reduce or to eliminate the number of road accident.