Psychopathologica1and immunological investigation of 95 patients sufferingfrom acute episodesof schizophrenia was carriedout. For the pwposes of ~le horrogcneitythe initial course ot treatment includedhaloperido! andamitriptylin in meantherapeuticdoses. 1bc result of the clinico-inununological investigation of intensive psychophll1Tnlcotherapy process showedceruin changesin the immunological indices whichmay be consideredan illustration of the influenceof the inwnunc processeson differenttypesof therapy reBCIions. The dynamic changesollhe immunological indices correlated with the rapid and effectivereductionof psychopathological disorders in intensive therapy. In cases or protractedepisodesthe immunological indices altered to a lesserdegree in comparison with the initialparameters. These indicesmay be considered predictors of therapyefficiency.

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IntroductionThe last years it is became clear that disturbances in molecular processes in pathological conditions can be connected with conformational changes in protein structure.AimInvestigation of blood albumin conformation in patients with melancholic depression.Material and methodsThere were investigated 19 patients with melancholic depression (12 women and 7 men) and 25 health volunteers. Patient's state according to ICD-10 criteria was defined as a depressive episode in the frame of bipolar depressive disorder (type 2) (F32) and in the structure of recurrent depressive disorder (F33). Subnanosecond laser time resolved fluorescence spectroscopy (SLTRFS) (subnanosecond diapason) with K-35 fluorescent probe was used for the investigation of albumin conformation.Results and discussionThere were revealed 3 binding sites in albumin molecule with fluorescent decay time of 1, 3 and 9 nanoseconds (A1, A3 and A9 sites, respectively) in healthy volunteers using SLTRFS approach. There were found significant differences between albumin binding sites of volunteers and patients with melancholic depression, respectively, А1–117 ± 7 и 142 ± 10; А3–358 ± 14 и 420 ± 26; А9–371 ± 16 и 433 ± 29.ConclusionThese findings point out that melancholic depression is followed by conformational changes of albumin molecule that can affect its functional properties. We can hypothesized that albumin binding properties can serve as a biomarker of the efficacy of psychopharmacotherapy.Disclosure of interestThe authors have not supplied their declaration of competing interest.

На сегодня проблема лечения красного плоского ли-шая слизистой оболочки рта (КПЛ СОР), особенно его эрозивно-язвенной формы, обладающей наибольшей по-тенциальной злокачественностью, представляет собой одну из важных и до конца не решенных задач клиниче-ской стоматологии [4,5].Самым значительным из первичных этапов ком-плексной терапии КПЛ, помимо этиотропной и патогене-тической терапии, является местное консервативное ле-чение. Современный подход к выбору эффективных мест-ных лекарственных средств (ЛС) при лечении заболева-ния диктует приоритет использования таких форм препа-ратов, которые обладают существенным преимуществом