Introduction: Caisson disease is one of the most common emergencies in divers with very common signs and symptoms that clinicians must be careful to identify based on a complete history and physical examination. The disease also requires immediate and definitive management, usually hyperbaric therapy for a better prognosis. Content: This article discussed the types, pathophysiology, and management of caisson disease caused by the release of nitrogen gas bubbles into the blood or tissues during or after a pressure drop in the environment. This is a disease that can be prevented by paying attention to existing risk factors. Summary: Caisson disease or decompression sickness is a collection of symptoms that are often encountered in archipelagic countries and can affect anyone diving for seafood or recreational activities. The symptoms are common, but by knowing the pathophysiology, clinicians can identify the disease and immediately perform therapy, thereby preventing complications such as arterial a gas embolism (AGE) so the mortality and morbidity due to caisson disease can be reduced.