Background: Ovarian cancer is still one of the neoplasms within the gynecology scope. Besides, World Health Organization (WHO) states that ovarian cancer ranks fourth cancer in women with the lowest five-year survival rate (43%). Thus, this research aims to recognize the risk factors in patients with ovarian cancer and the commonly found characteristic.Methods: This cross-sectional observational research on 29 women diagnosed with ovarian cancer observed the age, parity, body mass index (BMI), contraception, character, and stadium. The medical record samples based on patients’ registers were obtained from the Obstetrics and Gynecologic Polyclinic in Mangusada Badung Regional Public Hospital in the January–December 2019 period, and the result data were distributed using contingency tables. Results: The data dominantly diagnosed ovarian cancer, with age distribution 51-60 years (34.5%), 44.8% with obesity, 44.8% nullipara, without a history of contraceptive use, menarche within 12 years old (41.4%), diagnosed stage IIIC (42.3%), and with serous epithelial tumor subclassification (65.5%).Conclusions: Predominant ovarian cancer is found at a late stage. The most common risk factors of developing ovarian cancer, including the age of 51–60, obesity, menarche within 12 years old, and no history of hormonal contraceptive use, are consistent with this research hypothesis about risk factors dominantly found in patients with ovarian cancer

Background: Preterm labor is one of the most contributors to morbidity and mortality in perinatal and neonatal. Several factors may cause preterm labor with infection as pathophysiology, including urinary tract infection (UTI), to initiate inflammation cascade. This study aims to determine the relationship between bacteriuria and leukocytic factors with the incidence of preterm premature rupture of membrane (PPROM) and premature rupture of membrane (PROM) delivery at Mangusada Hospital, Badung in 2018-2019.Methods: A cross-sectional observational research toward 92 expectant within PPROM and 92 expectant within PROM was done to know the relation between leukocyturia and bacteriuria with the risk of PPROM and PROM. The research variable involves secondary data from urinalysis of leukocyturia and bacteriuria by flowcytometry Sysmex UX-2000 taken from the patient’s registry at maternity room Mangusada Hospital, Badung in 2018-2019. Data were analyzed using SPSS version 17 for Windows.Results: The study results show leukocyturia in PPROM is about 93.42% and 6.5% in PROM, while 71.67% bacteriuria within PPROM and 28.33% within PROM. There’s no significant relationship between bacteriuria result in PPROM and PROM (p=0.247), but there’s considerable relation between leukocyturia within PPROM and PROM (p=0.000).Conclusion: It can be concluded that there’s a significant relationship between leukocyturia within PPROM and PROM.  Latar Belakang: Persalinan preterm merupakan salah satu penyumbang besar morbiditas dan mortalitas perinatal dan neonatal. Berbagai faktor dapat menyebabkan persalinan preterm dengan mekanisme patofisiologi terutama infeksi, salah satunya infeksi saluran kemih (ISK), yang dapat menginisiasi kaskade inflamasi. Penelitian ini bertujuan untuk mengetahui hubungan faktor bakteriuria dan leukosituria dengan kejadian persalinan Preterm Premature Rupture of Membrane (PPROM) DAN Premature Rupture of Membrane (PROM) di RSUD Mangusada, Badung tahun 2018-2019Metode: Penelitian observational cross-sectional terhadap 92 ibu hamil bersalin dengan PPROM dan 92 ibu dengan PROM dilakukan untuk mengetahui hubungan antara bakteriuria dan leukosituria dengan risiko terjadinya persalinan PPROM dan PROM. Variabel penelitian berupa data sekunder hasil urinanalisa flowcytometry Sysmex UX-2000 (leukosituria dan bakteriuria) diambil dari register pasien di ruang bersalin Rumah Sakit Daerah Mangusada Badung tahun 2018-2019. Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Hasil penelitian menunjukkan leukosituria pada PPROM sebanyak 93.42% dan 6.5% pada PROM, sedangkan bakteriuria sebanyak 71.67% pada PPROM dan 28.33% pada PROM. Tidak ada hubungan yang bermakna antara kejadian bakteriuria dengan persalinan PPROM dan PROM (p=0,247). Namun, ditemukan hubungan yang bermakna antara leukosituria dengan persalinan PPROM dan PROM (p=0,000).Kesimpulan: Dapat disimpulkan terdapat hubungan signifikan antara leukosituria dengan persalinan PPROM dan PROM.

HIGHLIGHTS 1. Cardiovascular disease that occurs during pregnancy is the peripartum cardiomyopathy (PPCM).2. Literature on the association between preeclampsia (PE) and PPCM was reviewed.3. It was not certain whether PE is the independent risk factor of PPCM or an early predictor of PPCM development.   ABSTRACT Objectives: This paper aims to review the literature related to peripartum cardiomyopathy (PPCM) and preeclampsia (PE) in order to know their frequency and relationship and the current knowledge on their pathophysiology and management. Materials and Methods: The articles reviewed in this study were primary clinical studies published around 2016 and 2021, retrieved using Google Scholar and PUBMED databases. After several evaluations, 14-full-text studies written in English were examined. Results: Overall prevalence of PE in PPCM cases varied, about 9.9% - 44% in the individual studies. The lactation hormone prolactin and placental-derived anti-angiogenic factor soluble Fms-like tyrosine kinase 1 (sFlt-1), which had been known to be able to cause cardiac dysfunction, were elevated in both PE and PPCM. This partly explained the pathophysiology that the incidence of concurrent PE in women diagnosed with PPCM was four times more than that in the general population. Conclusion: Epidemiologic studies showed significant overlap between PE and PPCM patients. However, there were not enough good quality data to fully draw conclusions about the relationship between PE and PPCM, whether PE as the independent risk factor of PPCM or an early predictor of PPCM development.