No abstract

No abstract

No abstract

No abstract

Adsorptive stripping Voltammetric determination of irbesartan using a hanging mercury drop electrode (HMDE) is described. The method is based on adsorptive accumulation of the species at the HMDE, followed by a first-harmonic alternating current (AC) stripping sweep at pH 6. The behavior of the adsorptive stripping response was studied under various experimental conditions, e.g., type of supporting electrolyte, pH, accumulation time, scan rate, and mode of sweep. In Britton-Robinson buffer solution, a quasi-reversible reduction process involving transfer of two electrons and two protons takes place. The response was linear over the concentration range of 0.16 -1.60 mg/ml with regression coefficient 0.997 and detection limit 0.11 mg/ml. The average of determinations of the cited compound in oral dosages with its standard deviation was 99.39 ± 4.33 %.The result obtained by the proposed method was compared with that obtained by the uv-spectrophotometric technique. Furthermore, the proposed method was also successfully applied as a stability-indicating method.