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Melanotransferrin antibody (MA) and tamoxifen (TX) were conjugated on etoposide (ETP)-entrapped solid lipid nanoparticles (ETP-SLNs) to target the blood-brain barrier (BBB) and glioblastom multiforme (GBM). MA- and TX-conjugated ETP-SLNs (MA-TX-ETP-SLNs) were used to infiltrate the BBB comprising a monolayer of human astrocyte-regulated human brain-microvascular endothelial cells (HBMECs) and to restrain the proliferation of malignant U87MG cells. TX-grafted ETP-SLNs (TX-ETP-SLNs) significantly enhanced the BBB permeability coefficient for ETP and raised the fluorescent intensity of calcein-AM when compared with ETP-SLNs. In addition, surface MA could increase the BBB permeability coefficient for ETP about twofold. The viability of HBMECs was higher than 86%, suggesting a high biocompatibility of MA-TX-ETP-SLNs. Moreover, the efficiency in antiproliferation against U87MG cells was in the order of MA-TX-ETP-SLNs > TX-ETP-SLNs > ETP-SLNs > SLNs. The capability of MA-TX-ETP-SLNs to target HBMECs and U87MG cells during internalization was verified by immunochemical staining of expressed melanotransferrin. MA-TX-ETP-SLNs can be a potent pharmacotherapy to deliver ETP across the BBB to GBM.

a 5Gbps automatic gain control amplifier is presented with 27.8dB input dynamic range for 10GBase-LX4 Ethernet in 0.18um CMOS technology. Five push-pull inverters use self-bias resistors and inductive-series peaking technique to realize a variable gain amplifier (VGA). This VGA achieves 4GHz bandwidth and 20dB linear-in-dB gain tuning range. The proposed 5Gbps AGC amplifier yields constant output amplitude 100mV for an input 27.8dB dynamic range.

Polymer composite samples were prepared consisting of NC-826 epoxy and approximately 0.1–0.5 wt% aerographite nanomaterial. The compression properties of the various samples were evaluated at strain rates of 10−3–10−1 s−1 using a universal testing machine. The fracture surfaces of the tested samples were examined by scanning electron microscope. Additional composite samples consisting of NC-826 epoxy and 0.3 wt% multiwalled carbon nanotubes (MWCNTs) were prepared and tested under the same compression strain rates of approximately 10−1–10−3 s−1. In general, the results showed that the addition of aerographite nanomaterials to the resin matrix is beneficial in suppressing crack propagation under compression loads and therefore leads to an improved stress, toughness, and fracture strain compared to the pure resin sample. The results additionally showed that the use of MWCNTs as a reinforcement material yields a further small improvement in the mechanical properties of the sample.

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