The article describes a unique experience of repeated opistorchosis deworming in a patient who underwent orthotopic liver transplantation, which was required due to the development of complications of secondary biliary cirrhosis of parasitic etiology. Difficulties of differential diagnostics of hepatobiliary pathology, proceeding against the background of opistorchosis invasion, are discussed. The recent data on the parasitic morbidity in the territory of Khanty-Mansiysk Autonomous Okrug – Ugra is presented.