No abstract

Uracil-based antitumor preparations are widely used in oncological practice, which stimulates constant search for new, more effective analogs of these drugs [1 -3].The purpose of this work was to synthesize new compounds with potential antitumor activity, using substituted uracil or pyrimidine molecules as a base structure.

No abstract

REACTIONSOF THEOPHYLLINES. CHEMICAL CONVERSIONS OF 8-AMINOTHEOPHYLLINATES !. !. Kuz'menko and T. V. Zvolinskaya Thelvnallv stable, colored 8-aminotheophyllinates (hetaine derivatives o[ theophylline).[hlwl unstable, colorless salts with strong mineral acids and tmdergo partial decomposition to a uric acid upon plvlonged rcffhtxing with concentrated base solution. Substituted 8-pyridinium theophyllinates readily take part in tvpic'al reactions ~?/' the./imctional grotq~ in the substituted pyridine ring with retention r?/" the hetaine .~'truc'ture. The /ormation o/'the ,~Tnthesized compounds was coq/ilwwd by IR and NMR .wectroscot~y.

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