Continuous positive airway pressure (CPAP) improves autonomic activity in patients with chronic heart failure (CHF) and central sleep apnoea (CSA), but its effect on heart rate variability (HRV) during therapy has not been reported. We hypothesized that CPAP may decrease HRV, despite its beneficial effects on sympathetic overactivation, due to the expected stabilization of breathing. Sixty-seven CHF patients underwent polysomnography (PSG). Ten of them presented with CSA (age 66.1±8.5 years, apnoea-hypopnea index [AHI]=57.6±23.3, central AHI [cAHI]=41.6±24.6 [mean±SD]) and were subjected to a second PSG with manual CPAP titration. Beat-to-beat heart intervals for a 6-hour period of sleep were extracted from each recording and HRV was analysed. CPAP significantly reduced AHI (AHI=23.1±18.3 P=.004). Standard deviation of normal-normal interbeat interval (SDNN) (61.5±29.0 vs 49.5±19.3 ms, P=.021), root mean square of successive differences (RMSSD) (21.8±9.2 vs 16.4±7.1 ms, P=.042), total power (lnTP=7.8±1.1 vs 7.4±0.8 ms , P=.037), low frequency power (lnLF=5.5±1.5 vs 5.0±1.4 ms , P=.003) and high frequency power (lnHF=4.6±1.0 vs 4.0±1.0 ms , P=.024) were decreased. There was a strong correlation between the decrease in AHI and the decrease in lnHF (Spearman's ρ=.782). CPAP leads to a decrease in spectral and time domain parameters of HRV during therapy in CHF patients with CSA. These changes are best explained by the effect which CPAP-influenced breathing pattern and lowered AHI exert on HRV.

IntroductIon:Exogenous hypoxia increases ventilation and contracts the pulmonary vessels. Whether those factors change the values of nitric oxide in exhaled air has not yet been evaluated. objectIve: To examine the effect of exogenous normobaric hypoxia on the values of the fraction of nitric oxide in exhaled breath (FeNO). SubjectS аnd MethodS: Twenty healthy non-smoker males at mean age of 25.4 (SD = 3.7) were tested. The basal FeNO values were compared with those at 7 min. and 15 min. after introducing into the hypoxic environment (hypoxic tent), imitating atmospheric air with oxygen concentration corresponding to 3200 m above sea level. Exhaled breath temperature was measured at baseline and at 10-12 min. of the hypoxic exposition. Heart rate and oxygen saturation were registered by pulse-oximetry. results: All the subjects had FeNO values in the reference range. The mean baseline value was 14.0 ± 3.2 ppb, and in hypoxic conditions -15.5 ± 3.8 ppb (7 min.) and 15.3 ± 3.6 ppb (15 min.), respectively, as the elevation is statistically significant (p = 0.011 and p = 0.008). The values of exhaled breath temperature were 33.79 ± 1.55°С and 33.87 ± 1.83°С (p = 0.70) at baseline and in hypoxic conditions, respectively. Baseline oxygen saturation in all subjects was higher than that, measured in hypoxia (96.93 ± 1.29% vs. 94.27 ± 2.53%; p < 0.001). conclusIons: Exogenous hypoxia leads to an increase of FeNO values, but does not affect the exhaled breath temperature. . Исходные показатели FeNO были сопоставлены с показателями, полученными через 7 и 15 мин. после помещения в гипоксическую среду (гипоксическую палатку), которая имитировала атмосферный воздух с концентрацией кислорода, соответствующей концентрации на высоте 3200 м над уровнем моря. Температура выдыхаемого воздуха была измерена в начале и по истечении 10-12 мин. гипоксической экспозиции. Частота сердечных сокращений и сатурация кислорода были зарегистрированы при помощи записывающего пульсоксиметра. результаты: Все лица имели показатели FeNO в рамках референтного диапазона. Средний исходный показатель составлял 14.0 ± 3.2 ppb, а в гипоксических условиях -15.5 ± 3.8 ppb (7 мин.) и 15.3 ± 3.6 ppb (15 мин.), соответственно, при этом повышение было статистически значимым (p = 0.011 и p = 0.008). Показатели температуры выдыхаемого воздуха составляли 33.79 ± 1.55 °С и 33.87 ± 1.83 °С (p = 0.70), соответственно в начале и в условиях гипоксии. Исходная сатурация кислорода у всех лиц была выше измеренной в гипоксической палатке (96.93 ± 1.29 % vs. 94.27 ± 2.53 %;

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