the content of lipid hydroperoxides in the serum and liver mitochondria in animals in the late stages of ontogenesis (12 and 33 months old, Wistar male rats) was investigated. The possible effect of the food additive (“mix factor”) on these parameters in 33 months old animals, if they received this supplement from 22 months age daily throughout life in a dose of 0.05 - 0.06 ml / 100 g of body weight was determined. Moreover, the lifespan of animals was determined if they started taking a mix – factor from 22 months and from 30.5 months age. The influence of the mix – factor on the ability of old animals to perform work was determined in a separate series of experiments. It was shown that from 22 to 33 months the content of lipid hydroperoxides in mitochondria and serum increased by 23% and 41%, respectively. The activity of glutathione peroxidase in the serum, mitochondria and erythrocytes decreased, and the activity of glutathione reductase decreased only in the post-mitochondrial fraction of the liver. At the same time, malate– isocitrate dehydrogenase and 6-phosphate dehydrogenase remained unchanged in 33 months old animals compared with 12 months old animals. If animals from 22 months age received a mix factor with drinking water in a dose of 0.05-0.06 mg / 100 g of body weight every day until the end of life, the content of lipid hydroperoxides and the activity of glutathione peroxidase and glutathione reductase of 33 months old animals did not differ from 12 months old animals. The survival curve in animals receiving the mix factor was shifted to the right from 25 to 28 months of age compared with the survival curve of control animals. If animals began to receive the mix – factor at a very old age (from 30.5 months age) until the end of life, their lifespan was longer than that of the control animals. The last ones lived to 41 months, while the animals of the control group lived to 36 months. At the same time, the mix – factor increased the ability of old animals to do work in the test “running in treadmill”. Key words: aging, redox-system, geroprotectors, lifespan

DISCLAIMERTab) laaart «M pnaaiaJ » « aceoaol of work locatored by aa Miacy of the UaM SUM OIIIMHI Naaaa* lh« Uaa»4 SUM Gotmaaatt aor aay aaaacy tharaof, MraayoftMr aaaiayaaa, aakM aay warraly, turn* or iaaaM, or HMW aay ha*l liability or riajaaai bitty fcr lb« acoaraty, oawalataaait, or aaatalaaai of wry iaftfalioa, aaptratat, proaacl, or BNOM ihJiii*. or iiinnali tfeat Mi aw woaM aot iafriaa* arirtnly onaad rifatt. Rafar-LBL-91 Revised wot boraia to aay aaacaV CMMMTCMU proaact, proeoH, or Mviea by trade aaae, traaaaiark, UC-34C aaaafacaanr. or otbarwa* dew aot aaconariry coartkata or hasty •*> tadornamt, racoaMarch 1OR"? •laaatiia, or favoriag by tbc Uaited SUM Gowrameat or aay aracy thereof. The newt 1vidii.11 lyoj aad nahrioai of aathon «»rmid bareia do aot mccmrpy Mate or reflect tboae of tbe IMai SUM GonraaMat or aay afeacy thereof.

No abstract

No abstract

The article considers topical issues of information security in the activities of the National Police of Ukraine. It is determined that the main problem of information security in the law enforcement sphere arose due to the global contradiction between the possibilities of information technologies and the threats of their use. The settlement of the existing public information relations alone is insufficient, as the legislation does not keep pace with technical progress. The definition of "information security" is considered and the author's definition of this concept is offered. The main normative legal acts regulating the activity of the National Police in this direction are analyzed. It is stated that information security of the National Police of Ukraine is provided in two forms: organizational (related to the circulation, collection, processing, storage, use and protection of information); legal (preparation and approval of regulations (orders, instructions), development of regulations, instructions, algorithms, plans, etc.). The key to information protection is the administration of information systems. The European experience of information protection in the law enforcement sphere is considered. Attention is drawn to the need to implement a system of modern international information security standards ISO / IES series 27000, which is constantly updated. It is theoretically substantiated that: increasing the efficiency of the National Police of Ukraine can be solved through the introduction of a reliable information security system; to achieve the highest level of information security of law enforcement agencies it is necessary not only to improve the current legislation, but also to have a mechanism for its implementation; Security and protection in the information systems of the National Police should be based on a comprehensive approach to building a protection system, which provides for the integration into a single set of necessary measures and means of information protection at all levels of the information system.