Background:The current study was designed to determine the relation between preoperative cerebral oxygen saturation (ScO 2 ), variables of cardiopulmonary function, mortality, and morbidity in a heterogeneous cohort of cardiac surgery patients. Methods: In this study, 1,178 consecutive patients scheduled for on-pump surgery were prospectively studied. Preoperative ScO 2 , demographics, N-terminal pro-B-type natriuretic peptide, high-sensitive troponin T, clinical outcomes, and 30-day and 1-yr mortality were recorded. Results: Median additive EuroSCORE was 5 (range: 0 -19).Thirty-day and 1-yr mortality and major morbidity (at least two major complications and/or a high-dependency unit stay of at least 10 days) were 3.5%, 7.7%, and 13.3%, respectively. Median minimal preoperative oxygen supplemented ScO 2 (ScO 2min-ox ) was 64% (range: 15-92%). ScO 2min-ox was correlated (all: P value Ͻ0.0001) with N-terminal pro-Btype natriuretic peptide (: Ϫ0.35), high-sensitive troponin T (: Ϫ0.28), hematocrit (: 0.34), glomerular filtration rate

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