Winemaking by-products account for more than 30% of the grape production, but this inexpensive feedstock has not yet been fully exploited. Accordingly, we evaluated the potential biological activity of winemaking by-products produced with Syrah grapes in comparison with those of the wine produced using the same grape cultivar. Winemaking by-products showed higher contents of total anthocyanins, flavonols, stilbenes, and flavanols than red wine as evaluated by HPLC-DAD-FD (on a dry weight basis). In contrast, red wine was a better source of phenolic acids. However, the contribution of phenolic acids was minor for both samples. Furthermore, equivalent concentration of winemaking by-products (100 mg/kg/d) showed greater biological activity by than that of red wine by decreasing the levels of VLDL-cholesterol and triacylglycerols in Wistar rats. Therefore, this study supports the use of winemaking by-products as an economical source of bioactive phenolics with potential use in the food and nutraceutical industries.

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Resumo:As arboviroses Dengue, Zika e Chicungunya são importantes problemas globais de saúde pública, que podem ser transmitidas, principalmente, durante o repasto sanguíneo do mosquito Aedes aegypti. A prevenção destas doenças é realizada comumente através do controle ambiental do inseto por métodos químicos, físicos ou biológicos, em seus estágios larval e/ou adulto. Produtos naturais têm sido estudados como alternativas químicas mais seguras e eficazes, empregando-se extratos, frações e compostos isolados. Baseados em um artigo de Santos e colaboradores, os quais relatam a atividade larvicida de monoterpenos e compostos análogos em Aedes aegypti, este trabalho apresenta uma forma não usual de seleção de variáveis, baseada no AbstractThe arboviruses Dengue, Zika and Chicungunya are global public health problems that can be mainly transmitted by the bit of the Aedes aegypti mosquitoes. The prevention of these diseases involves the insect control, by chemical, physical or biological methods, considering both larval and adult stages. Natural products have been studied as more secure and effective chemical alternatives, through the use of extracts, fractions, and isolated compounds. Based on the previous paper of Santos and coworkers, which related the larvicidal activity of monoterpenes and analogs against Aedes aegypti, this work presents an unusual variable selection procedure, based on Clustering Coefficients of Variation (CCV) method, aiming to generate a classification model by SIMCA, capable of helping in the search of compounds with greater larvicidal potential.