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C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with l l l l n to form kinetically inert radiolabelled complexes.

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A general synthetic method for the synthesis of 1 ,&disu bstituted derivatives of the 14-membered tetra-aza macrocycle, 'cyclam', involves selective ditosylation: in the Cu2+ complex of the lr8-diacetic acid derivative, the copper is six-co-ordinate with elongated Cu-0 interactions and this macrocycle undergoes lactamisation to form a paracyclophane-like tricyclic lactam which is resistant to acidic hydrolysis.