Dyslipidemia is a disorder of lipid metabolism and one of the modifiable risk factors for cardiovascular disease. The prevalence of dyslipidemia based on raised total cholesterol in the world was 39%, of which 37% for men and 40% for women. Cholesterol-lowering drugs have been reported to have many side effects. One alternative medicine in reducing blood cholesterol levels by utilizing the potential of the avocado peel. This research was experimental with a pre-posttest control group design. This research was used 30 Sprague Dawley male rats divided into 6 groups, namely the normal control group (CG1), negative control (CG2), positive control (CG3) and 3 treatment groups (TG) who received avocado peel extract (APE) at 75, 150, and 300 mg/200gr bodyweight rats. Data were tested using a one-way ANOVA. The results showed that APE significantly reduced the levels of LDL-C (P<0.05) was 17.82±2.62, 29.62±2.00, and 36.33±4.47 mg/dl (TG1, TG2, TG3). Decreased triglycerides levels (P<0.05) of 1.62±4.17, 14.05±5.16, and 29.67±5.79 mg/dl (TG1, TG2, TG3). The increased levels of HDL-C (P<0.05) were 29.67±5.79, 22.63±4.82, and 34.35±2.72 mg/dl (TG1, TG2, TG3). Avocado peel (Persea americana Mill.) extract showed a hypolipidemic effect by reducing LDL-C, triglycerides, and increasing HDL-C levels in rats with dyslipidemia.