Objective. To develop a new way to enhance single-layer colonic anastomosis with oksitselanim tissue and to assess its effectiveness in comparison with anastomosis, reinforced by latex tissue adhesive (LTA). Material and methods. The study was performed on 48 white mongrel male rats. Both the groups underwent intersection of the colon with subsequent formation of anastomosis in an «end-to-end» single-row Pirogov-Mateshuk suture that in the control group was strengthened by latex tissue adhesive, and in the experimental group by oksitselanim tissue. The derivation of the experiment was carried out on 3, 7, 14, 30 days. Such parameters of blood as wbc, phagocytic index, phagocytic number, the level of circulating immune complexes, the activity of complement were studied. The swab was taken from the anastomosis zone for bacteriological examination. The presence of effusion, adhesions, abscess, anastomotic narrowing, expansion of the leading department were macroscopically evaluated. The mechanical strength of the anastomosis was determined by pneumohydropression method. The area of tanastomosis was taken for histological examination. Results. The comparison of the morphological patterns of the abdominal cavity, the results of microscopic and bacteriological study suggests a lower expression of local inflammatory changes and bacterial permeability of colonic anastomoses reinforced with «oksitselanim» tissue. The mechanical strength of anastomoses in the experimental group exceeds those in the control group. The comparative analysis of leukocyte counts, phagocytosis, levels of circulating immune complexes and complement activity suggests a more rapid and less intense non-specific inflammatory response in the experimental group. Conclusion. The «oksitselanim» preparation makes it possible to prevent quickly the development of infectious complications with minimal response of the body and provide better conditions for the tissue regeneration after the formation of intestinal anastomosis.

Background. The advances in surgical treatment of chronic pancreatitis (CP) have significantly reduced postoperative mortality rate, however, the number of deaths remains high. Thus, prevention and prediction of complications are regarded as a complex and important task in choosing optimal surgical strategy. Objective. To study early postoperative complications after proximal pancreatic resection in chronic pancreatitis; to determine surgical strategy in preoperative and postoperative stages to reduce the risk of and predict postoperative complications. Material and methods. From 2001 to 2019 on the basis of the Vitebsk Regional Clinical Hospital, 246 patients with CP and its complications were operated on, among them there were 223 (90.7%) men and 23 (9.3%) women. The mean age was 48(±6) years. Our study did not include patients who underwent Frey's operation and pancreatoduodenal resection due to their small number. Results. Of 246 operated patients, early postoperative complications occurred in 126 (51.2%) patients. Among them after the Beger’s operation - in 77 (31.2%) patients, after the Berne modification of the Beger’s operation - in 49 (20%) patients, respectively. Of the 126 patients with developed postoperative complications, repeated surgical interventions were performed in 50 (39.7%) patients - 35 (70%) patients after the Beger’s operation and 15 (30%) patients after the Berne modification of the Beger’s operation, respectively; in 76 (60, 3%) patients, postoperative complications were controlled by conservative measures. In order to manage early postoperative complications, various types of surgical interventions were performed. Conclusions. Patients with pancreatic calcification, virsungectasia, virsungolithiasis in combination with portal hypertension are more likely to develop early postoperative complications during the Beger’s operation, in comparison with the Berne modification of the Beger’s operation. In patients with pancreatic calcification, virsungectasia and virsungolithiasis in combination with portal hypertension, as well as in patients with pancreatic head cysts, it is advisable to perform the Berne modification of the Beger’s operation, it being technically simpler thus allowing to minimize the number of postoperative complications. When performing the Beger’s operation, as compared to the Berne modification of the Beger’s operation, there were no statistically significant differences in the total number of repeated interventions aimed to correct early postoperative complications, however, after the Beger’s operation, the complications were statistically significantly more often managed by minimally invasive intervention (p=0.005).