Biopharmaca is a biological preparation that comes from nature that has properties as a medicine. Biopharmaca products are categorized into three types, namely herbal medicine, standardized herbal medicine (OHT), and phytopharmaca. The research objective is to find out the benefits of biopharmaca products in leading a healthy Indonesia. Qualitative descriptive research with the method of collecting data is observation and recording documents. The results show that the benefits of biopharmaca products can improve health in the community, are more effective, more affordable, and have relatively smaller side effects. The use of biopharmaca products has global competitiveness that is utilized by residents of several countries such as: China (People’s Republic of China) reaching 90%, Chile reaching 71%, Colombia reaching 40%, France reaching 49%, Canada reaching 78%, Britain reaching 60%, The United States reached 42%, and Germany reached 73%. In moving towards a healthy Indonesia, biopharmaca products can be utilized. Based on the results of the research that biopharmaca products can be used in formal health services to improve the quality and degree of health in the community towards a healthy Indonesia.

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Aloe vera (Aloe barbadensis Miller) contains anthraquinone compounds, flavonoids and saponins which are thought to have antibacterial effects so as to inhibit bacterial growth. The purpose of the study was to determine the inhibitory power of Aloe barbadensis Miller on the growth of Staphylococcus aureus bacteria. The pure experimental study was conducted with The Randomized Posttest Only Control Group Design using six (6) treatments, namely aloe vera extract with a concentration of 25%, 50%, 75%, 100%, Chloramphenicol 30 mcg antibiotics as a positive control, and sterile aquadest as a control negative for Staphylococcus aureus bacteria grown on Mueller Hinton media. After being treated, it was incubated for 24 hours and measured its inhibitory power. The growth inhibition data of Staphylococcus aureus bacteria in the form of inhibition zone diameter was analyzed statistically by Kruskal Wallis test, at the level of confidence α = 0.05. The results showed that the average inhibitory effect of Aloe vera extract on the growth of Staphylococcus aureus bacteria in concentrations of 25%, 50%, 75% and 100% were 0 ± 0 mm; 7.125 ± 0.1250 mm; 8.375 ± 0.23936 mm; and 9.0 ± 0.40825 mm. Based on the results of the study concluded that aloe vera extract can inhibit the growth of Staphylococcus aureus bacteria. The higher the concentration of Aloe vera extract the greater the inhibitory effect on the growth of Staphylococcus aureus bacteria.

Sore throat is a respiratory infection caused by a bacterial infection of Streptococcus pyogenes. Betel leaf is used for loloh (traditional medicine) which has antimicrobial activity. The purpose of this study was to determine the content of active compounds and the antibacterial activity of the boiled water and juice of betel leaf against Streptococcus pyogenes. Explorative research using GC-MS method was used to identify and determine the abundance (content) of active compounds from loloh while the experimental research with the Randomized Post Test Only Control Group Design was carried out by treating the samples in four groups those are the negative control group with distilled water, the positive control group with 30 μg vancomycin, the treatment group with boiled water of betel leaf and betel leaf juice water to prove the antibacterial activity of loloh. The antibacterial activity data of the study results were analyzed statistically nonparametric through the Kruskal-Wallis test. The results showed that the betel leaf boiled water contained 0.472% hydroxicavicol active compound and had an average antibacterial activity of 6.50±0.224 mm against Streptococcus pyogenes bacteria. Whilst the juice of betel leaves did not contain active compounds and had no antibacterial activity.

The rhizome of the bangle contains antibacterial compounds including saponins, flavonoids, essential oils, and tannins. The aim of the study was to determine the inhibitory power of bangle rhizome extract on the growth of Staphylococcus aureus bacteria. True research - experiment with posttest design with control group was carried out by giving 6 treatment groups, namely negative control group (K-) using aquadest, positive control group (K +) using 30 mcg Chloramphenicol antibiotics, 25% ( PE1), 50% (PE2), 75% (PE3), and 100% (PE4) of concentration of rhizome extract treatment. After the treatment is complete, the inhibition is measured. The research data were analyzed statistically by Kruskall Wallis non parametric test and Sperman Rang correlation test. The results showed that the average inhibition of bangle rhizomes in each group in groups K-, K+, PE1, PE2, PE3, and PE4 were 0.000 ± 0.000, 25.000 ± 0.408, 14.250 ± 0.479, 16.500 ± 0.289, 17.750 ± 0.250, 19,500 ± 0.289 differ significantly (p <0.05). There was a very significant positive correlation between the concentration of rhizome bangle extract and the growth inhibition of Staphylococcus aureus bacteria (r count of 0.967 (**)> r table which was 0.503 at α = 0.05 and n = 24 or p <0.01). Conclusion: bangle rhizome extract at concentrations of 25%, 50%, 75%, and 100% has a strong inhibitory power against the growth of Staphylococcus aureus bacteria. The higher the concentration the greater the inhibitory power.