. In the rat, both spironolactone (an antimineralocorticoid) and norbolethone (an anabolic steroid) inhibit the characteristic neuromuscular disturbances and the mortality produced by digitoxin, gitalin, proscillaridin, digoxin and digitalin. The corresponding effects of strophanthin K, ouabain and digitoxigenin could not be prevented. . It may be concluded that, in our experimental conditions, both spironolactone and norbolethone counteract the toxicity of some, but not all, digitalis compounds tested and that both the protective steroids affect the toxicity of the same digitalis derivatives. . This antidigitalis effect is not merely a secondary consequence of either antimineralocorticoid or anabolic potency because spironolactone lacks anabolic and norbolethone lacks antimineralocorticoid properties. Indeed, it appears that the ability to antagonize the toxicity of digitalis compounds represents a pharmacological property independent of all known steroid hormone actions, since spironolactone is virtually devoid of these.

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The subcutaneous calcification effected in the rat at sites directly treated with calcergens, such as lead acetate, CeCl(3), CaCl(2), and KMnO(4), is inhibited by simultaneous local application of various calciphylactic challengers, but not by many other compounds.

Experiments on rats indicate that, with very few exceptions, the calcification which occurs at subcutaneous sites of treatment with lead acetate, cerium chloride, calcium chloride or potassium permanganate is completely blocked or severely inhibited by simultaneous topical application of calciphylaetic challengers but not of non-challengers. Despite the few exceptions (which are thought to depend upon specific chemical interactions between some of the compounds tested) this singular correlation between calciphylactic challenging and anticalcergic potency, is highly significant by the Chi-square-test (P< 0.001).Key words: Calcergy --Calciphylaxis ~ Calcium --Metals.Chez le rat, des experiences ont montr6 que, saul de rares exceptions, les calcifications produites au site d'injeetion d'ac6tate de plomb, de chlorure de c6rinm, chlorure de calcium ou de permanganate de potassium sent compl~tement pr6venues ou fortement inhib6es par l'application locale simultan6e de provocageurs calciphylactiques, mais non par des agents non provocateurs. Malgr6 quelques exceptions (attribu6es ~ des interrelations chimiques sp6cifiques entre certaines des substances utilis6es), cette curieuse corr61ation entre l'efficacit~ calciphylactique provocatrice et le pouvoir anticalcergique est, d'apr~s le test gs, hautement significative (P < 0,001).Nach subcutaner Injektion yon Bleiacetat, Ceriumchlorid, Calciumchlorid oder Kaliumpermanganat tritt an der Injektionsste]le eine starke Verkalkung auf. Bis auf sehr wenige Ausnahmen kann diese durch gleichzeitige lokale Anwendung yon calciphylaktischen Provokatoren verhfitet oder weitgehend unterdriickt werden. In dieser Beziehung sind nicht provolatorisch wirkende Stoffe inaktiv. Trotz der wenigen Ausnahmen (die wahrscheinlich auf spezifische, chemische Wechselwirkungen zwischen manchen der untersuchten Substanzen beruhen) ist dieser merkwiirdige Zusammenhang zwischen calciphylaktisch provozierender und anticalcergischer Aktivit~t, nach dem g2-Test berechnet, statistisch hochsignifikant (P< 0,001).

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