Психофизиологические и иммунологические характеристики больных бронхиальной астмой и здоровых мужчин с различной функциональной асимметрией мозга Абрамова Т.Я., Смык А.В., Соловьева И.Г., Демина Д.В., Леонова М.И., Труфакин С.В., Абрамов В.В.
НИИ клинической иммунологии СО РАМН, г. НовосибирскРезюме. На основании анализа собственных и литературных данных обосновывается взаимос-вязь психофизиологических и иммунологических параметров у здоровых людей и у больных брон-хиальной астмой. Главный акцент делается на выяснении роли функциональной асимметрии мозга, как базового феномена, определяющего особенности психической деятельности, а также вегетатив-ной и иммунологической активности. Possible interactions between psychophysiological and immunological parameters are documented in healthy persons and bronchial asthma patients, as based on our own data and other sources. A role of functional asymmetry of brain is regarded as a basic phenomenon determining main features of psychical activity, as well as functions of autonomous nervous system and immunological activity.
Immune dysregulation syndromes (CTLA4 and LRBA deficiency) belong to the combined primary immunodeficiencies with defective tolerance due to lack of T regulatory lymphocytes function and resulting autoimmune complications. One of them is interstitial lymphocytic lung disease (ILLD), caused by pathologic bronchi-associated lymphoid tissue hyperplasia, progressive loss of lung function and decreased life expectancy. ILLD diagnosis is based on pathomorphological lung changes and radiologic symptoms. Targeted therapy with Abatacept in patients with immune dysregulation syndromes provides control of the autoimmune complications, including ILLD and is well tolerated. Here we demonstrate two cases of patients with immune dysregulation syndromes and ILLD treated with Abatacept.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.