Relevance. Humanity has been confronted with the global spread of dangerous viral diseases for centuries. Today a new coronavirus, SARSCoV-2, has been added to the list of potentially pandemic pathogens.The purpose of the article is to highlight, as much as possible, the physical and chemical properties of coronavirus, its epidemiology, framework for the disease prevention and treatment in various population groups and healthcare workers. The article provides a list of regulatory documents, a detailed guidance for healthcare professionals on how to act in case of identifying a patient with suspected COVID-19 in healthcare facilities, and a description of the coronavirus disease outbreak situation in the world and in the Russian Federation.Conclusions. The sanitary protection of the territories of the countries represents the main way to shield a population from a dangerous infectious disease. Therefore, the collaboration of physicians from all over the world and constant exchange of information among them is of crucial importance. The COVID-19 pandemic requires decisive, coordinated, global quarantine measures; biological protection of the population, collaboration on the vaccine’s development and treatment methods, and joining efforts against the panic and misinformation.
Relevance. Humanity has been confronted with the global spread of dangerous viral diseases for centuries. Today a new coronavirus, SARSCoV-2, has been added to the list of potentially pandemic pathogens.The purpose of the article is to highlight, as much as possible, the physical and chemical properties of coronavirus, its epidemiology, framework for the disease prevention and treatment in various population groups and healthcare workers. The article provides a list of regulatory documents, a detailed guidance for healthcare professionals on how to act in case of identifying a patient with suspected COVID-19 in healthcare facilities, and a description of the coronavirus disease outbreak situation in the world and in the Russian Federation.Conclusions. The sanitary protection of the territories of the countries represents the main way to shield a population from a dangerous infectious disease. Therefore, the collaboration of physicians from all over the world and constant exchange of information among them is of crucial importance. The COVID-19 pandemic requires decisive, coordinated, global quarantine measures; biological protection of the population, collaboration on the vaccine’s development and treatment methods, and joining efforts against the panic and misinformation.
Гемодинамические показатели у больных артериальной гипертонией на фоне терапии амлодипином, фозиноприлом и метопрололом А.Л. Хохлов, М.И. Шуникова, А.Ю. Соснин, И.Н. Каграманян, Л.А. Лисенкова Кафедра клинической фармакологии, Ярославская государственная медицинская академия, Клиническая больница №2, Ярославль Цель. Оценить эффективность антигипертензивной терапии антагонистом кальция (амлодипин), ингибитором ангиотензинпревращающего фермента (фозиноприл) и β-блокатором (метопролол) у больных артериальной гипертонией (АГ) с учетом влияния на центральную и периферическую гемодинамику. Материал и методы. Обследовано 60 пациентов с АГ I-II стадии, 1-2 степени. Пациенты были разделены на 3 группы. Больные 1-й группы получали амлодипин (Тенокс) в дозе 5-10 мг/сут, 2-фозиноприл (Моноприл) 10-20 мг/сут, 3-метопролол (Метокард) в дозе 50-200 мг/сут. При необходимости больным каждой группы добавляли диуретик. До начала и через 6 мес лечения проводили суточное мониторирование артериального давления (АД), эхокардиографию, ультразвуковое иссдедование брахиоцефальных артерий и магистральных артерий головы, пробу с реактивной гиперемией и нитроглицерином. Результаты. Амлодипин, фозиноприл и метопролол были равны по антигипертензивной эффективности. Амлодипин в большей степени снижал массу миокарда и улучшал диастолическую функцю левого желудочка по сравнению с фозиноприлом и метопрололом. Амлодипин и фозиноприл положительно влияли на сосудистое ремоделирование. Метопролол уменьшал утренний подъем АД и частоту сердечных сокращений, однако не влиял на вариабельность систолического АД. Заключение. При равной антигипертензивной эффективности амлодипина, фозиноприла и метопролола их влияние на сердце и сосуды, показатели суточного ритма АД и гемодинамику различается. Ключевые слова: артериальная гипертония, диастолическая дисфункция, вариабельность артериального давления, гемодинамика, эндотелиальная функция РФК 2007;4:33-38 Effects of amlodipine, fosinopril and metoprolol on hemodynamics in hypertensive patients
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