Modern standards of laboratory animal Science include wor�ing with laboratory animals of high quality�� in �articular�� with s�ecific �athogen free (SPf� mice and rats. on the other hand�� assisted re�roductive technologies (arT� are widely used in modern medicine for human infertility treatment as well as for genome resource ban�ing. in the �resent study�� a com�arison of body weight�� blood �ressure (BP� and behavior in the «elevated �lus maze» (EPM� test was made between three grou�s of iSiaH (inherited stress induced arterial hy�ertension� rats�� a grou� of animals that were born and raised in a conventional animal facility and two grou�s from an SPf animal facility (one with animals born naturally and another with animals resulting from arT�. There were no changes in BP between the grou�s�� but the behavior of iSiaH differed de�ending on rearing conditions. in �articular�� grooming time�� as well as the number of defecations and the number of urinations during the test were decreased in both grou�s of iSiaH rats born in the SPf animal facility as com�ared to iSiaH rats born in the conventional animal facility. The behavior of the iSiaH rat offs�ring resulting from arT was different from that of the naturally born grou��� the EPM test revealed reduced anxiety in the former. The results of the �resent study indicate that the rearing conditions as well as re�roductive technologies affect some behavioral characteristics in adult iSiaH rats�� although they develo� arterial hy�ertension in all the conditions used in this study.Key words�� iSiaH rats; blood �ressure; assisted re�roductive technologies; behavior.Современные стандарты в исследованиях на ла�ораторных животных направлены на то�� �то�ы ра�отат�� с ла�ораторными животными высокого ка�ества�� в �астности со сво�одными от специфи�еских патогенов (SPf� мышами и крысами. С другой стороны�� вспомогател��ные репродуктивные технологии (ВРт� широко испол��зу�тся в современной медицине для ле�ения �есплодия �еловека�� а также для создания крио�анков генети�е-ских ресурсов. В данной ра�оте проведено сравнение массы тела�� артериал��ного давления (�Д� и поведения в тесте «приподнятый крестоо�разный ла�иринт» (���л� трех групп крыс линии НИС�Г (наследственная индуцированная стрессом артериал��ная гипертензия��� группа крыс�� рожденных и выращенных в конвен-ционал��ном виварии�� и двух групп из SPf-вивария (рожденных естественным путем и полу�енных путем применения репродук-тивных технологий�. Разли�ий по вели�ине �Д между исследуе-мыми группами о�наружено не �ыло�� но выявлены разли�ия в поведении крыс линии НИС�Г при разных условиях содержания. Время груминга�� а также �исло актов дефекации и уринации за время теста �ыло достоверно ниже у крыс о�еих групп�� родив-шихся в условиях SPf-вивария�� по сравнени� с крысами�� рожден-ными в условиях конвенционал��ного вивария. �оведение крыс линии НИС�Г�� рожденных при помощи ВРт�� отли�алос�� от поведения крыс линии НИС�Г�� рожденных естественным путем. тест ���л выявил снижение тревожности у первых. Резул��таты данного и...

Modern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications often use the term “Syndrome of megalopolis”, which means disruption of sleeping, high anxiety, and altered reproductive function. Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. Long-lasting distress may worsen health in general and suppress reproductive function, in particular. The review presents the data on the effects of maternal stress on folliculogenesis, especially when assisted reproductive technologies (ARTs) are used. Clinical data are presented alongside data from laboratory animal experiments. Different maternal stress models are taken into account in respect of their inf luence on oocyte maturation and embryo development. The interfering of psycho-emotional stress and reproductive function is the focus of the review. In these situations, exogenous hormones compensate for the stress-related disruption of the hypothalamic-pituitary-gonadal axis. When ARTs are implemented, stress-induced disruption of oogenesis is realized not via a decrease in hypothalamic and pituitary hormones, but by other ways, which involve paracrine mechanisms described in this review. Based on the literature analysis, one may conclude that stress negatively affects oocyte maturation in the ovary and suppresses subsequent embryo development. The role of some ovarian paracrine factors, such as BDNF, GDF-9, HB-EGF, TNF-α, and some others has been elucidated.

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