Case ReportThyr otoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by episodes of muscle weakness and hypokalemia. TPP is often not recognized at first attack due to a very low prevalence among the Caucasian population and usually mild symptoms of hyperthyroidism. We report a case of TPP due to Graves' disease in a Caucasian male, who presented with 4 paralytic episodes before the diagnosis was made. Case ReportA 37-year-old Caucasian man was admitted at the hospital for evaluation of episodic muscular weakness. He recalled four similar episodes in the previous 4 months, which started during sleep or post-exercise rest. Attacks consisted of flaccid muscle weakness that varied from mild proximal leg weakness to quadriparesis, involving mainly the lower-limbs. Three attacks resolved spontaneously over 2 to 8 hours. Hypokalemia (2.3 mEq/L) and mild hypomagnesemia (1.53 mg/dL) were documented in one episode and managed with administration of intravenous potassium chloride in the emergency department. In this attack, proximal flaccid quadriparesis 2/5 was observed, with normal reflexes and sensory examination. The electrocardiogram was normal.Two weeks later (between episodes) laboratory studies revealed normal renal and hepatic function, and the following results: serum sodium 143 mEq/L (136-145), potassium 3.6 mEq/L (3.50-5.10), calcium 9.03 mg/dL (8.27-9.80), albumin 34.5 g/L (34-48), urine sodium 77 mEq/L (25-150), urine potassium 93mEq/L (17-83). He had no significant personal or familial medical history and he was not taking any medication. He related weight loss, distal tremor, and heat Keywords: Hyperthyroidism; Hypokalemia; Thyrotoxic periodic paralysisWe describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. Hypokalemia was documented in one episode and managed with intravenous potassium chloride. Hyperthyroidism was diagnosed 4 months after onset of attacks because of mild symptoms. The patient was subsequently diagnosed as having thyrotoxic periodic paralysis associated with Graves' disease. Treatment with propranolol and methimazol was initiated and one year later he remains euthyroid and symptom free. Thyrotoxic periodic paralysis is a rare disorder, especially among Caucasians, but it should always be considered in patients with acute paralysis and hypokalemia, and thyroid function should be evaluated.

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