Table 1 GRADE CPC n (%) 5-FU n (%) Anorexia G1-2 4 (12.5) 8 (18.2)

No abstract

methods A cross-sectional study in the Paediatrics Emergency Care Unit was used as pilot test. The day the study was completed, the relation of registered children in the unit was obtained via an informatic program. Both demographic (age and weight) and clinical (symptomatology, complementary tests, diagnosis and discharge treatment) were registered. For each patient, adequacy of the prescribed antibiotic, indication and dose adjustment to weight and age, were analysed. Results From the 114 assessed patients, 16 (14%) were treated with antibiotics and recruited for follow-up. The most common diagnosis was tonsillitis (25%), acute bronchitis (19%) and otitis media (19%), being the remaining percentage cases of appendicitis, urinary tract infections, nasopharyngitis, cellulitis and laryngitis. From the 16 prescribed treatments, 12 were susceptible of recommendation.The main identified causes for treatment modification were an excessive duration (50%), an inadequate dose for either shortage (25%) or excess (8%) or a suboptimal antibiotic choice (17%). Conclusion and relevanceResults showed a low adequacy of the antibiotic treatments, thus evidencing the need for a PROA that improves the prescription quality and guarantees patient safety. Members from the PROA group must ensure education about antibiotics prescription, emphasising the features of children as a population group and sharing the local antibiotic guide from the hospital.

Aim and objectives To analyse the effectiveness of a pharmaceutical intervention to prevent the potential interaction between integrase inhibitors and vitamin supplements or antacids.Material and methods Retrospective study conducted between May and September 2021. Patients were included if they were on treatment with ART containing an integrase inhibitor, both naive and continuation, and if they attended the pharmacy outpatient service during the study period.Demographic (sex and age) and pharmacological variables were collected. It was also documented whether patients were taking their treatment adequately and, if not, whether they were committed to modifying their medication management.Results One hundred and thirty-five patients treated with antiretroviral therapy (ART) containing raltegravir, dolutegravir, elvitegravir, bictegravir or cabotegravir were interviewed. Mean age was 47 years and 72% were men.33% of the patients confirmed that they took a multivitamin and mineral complex daily and 21% took antacids occasionally.Pharmaceutical advice was given to these patients using infographics to help them understand how to take their treatments properly (taking ART 2 hours before or 6 hours after multivitamins or antacids). 80% of these patients were not taking their therapy properly due to lack of information and 100% of them committed to following the pharmaceutical advice in order to improve the effectiveness of their treatment.Two months later, the counselled patients were contacted by telephone and 92% confirmed that they were following the pharmacist's recommended guidelines. The remaining 8% could not be contacted. Conclusion and relevanceThis study shows a large population that takes non-prescription drugs and is uninformed. Patients should be adequately interviewed during dispensing of treatment to find out what other non-prescription medicines they are taking in order to effectively prevent drug-drug interactions and to optimise ART.

No abstract