Plasma glucose and pancreatic-glucagon-like immunoreactivity (GLI) were measured in normal subjects and in patients with chronic pancreatitis after an intravenous insulin injection. Both groups showed a fall of about 40 mg/100 ml in plasma glucose at from 0 to 30 minutes. In the normal group, the pancreatic GLI increased significantly above the 0-value at 30 and 60 minutes. No increase was observed in the pancreatitis patients. In all cases a decrease in gut GLI was observed during the test.

After a two week washout period 25 patients with moderate to severe essential hypertension were treated with pindolol. In 12 patients the reduction in blood pressure was excellent and treatment with pindolol was continued. In 13 patients treatment was supplemented subsequently with clopamide and 12 patients had a satisfactory result. Side-effects were few and mild.

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Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Visken) combined with hydralazine. Hydralazine caused a statistically significant reduction in blood pressure and an increase in pulse rate as compared with the placebo: palpitations were an irritating side-effect. The combination of hydralazine and pindolol resulted in an additional fall in blood pressure (p less than 0.001) and the pulse rate decreased (2 p less than 0.001). The combined treatment also had a favourable effect on palpitations and angina pectoris.

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