Pseudoangiomatous Stromal Hyperplasia (PASH) is a benign breast tumor with a histological pattern that mimics the appearance of angiomatous proliferation. The lesion appears as a complex tissue with slit-like spaces lined by spindle cells resembling endothelial cells with a background of stromal hyperplasia. PASH manifests as a palpable mass, multifocal nodules, or a large diffuse mass that makes the breast asymmetrical. We report a case of breast lump in a 32-year-old woman caused by PASH. Biopsy of the mass showed histopathologic features of PASH. This patient then received tumor excision to remove the mass. Treatment of PASH tumors depends on the size and growth rate of the tumor. Anti-hormonal therapy such as tamoxifen may be an option for non-invasive therapy, but after the diagnosis has been confirmed through a core biopsy and the tumor size is no more than 2 cm. Surgical excision of the tumor by minimizing damage to the surrounding breast tissue is the most recommended treatment.

Background: Breast cancer is the most common cancer diagnosed in women. It basically caused by a progressive accumulation of genetic disorders. Vitamin D and its receptor (VDR) have been shown to have an effect on the carcinogenesis of breast cancer. Several studies have shown VDR Apa1 polymorphisms became the most prevalent polymorphism of other polymorphism variants of breast cancer. There are still lack of studies that review the relationship of VDR gene polymorphisms, especially Apa1 on breast cancer risk among Balinese woman.Method: This study was a case-control design- analytic study to see the relationship between Vitamin D receptor Apa1 gene polymorphism and breast cancer risk in Balinese women. There were 42 venous blood samples from breast cancer women and healthy women in Bali. This study was carried out at the Faculty of Medicine Integrated Biomedical Laboratory. DNA isolation was done for sequencing to determine the sequence of gene bases. Then the data were analyzed using SPSS 16.Results: Univariate analysis showed the characteristics of the subject and research variables. Bivariate analysis showed that the presence of VDR Apa1 polymorphism in Balinese women increased the risk of breast cancer by 5,846-fold higher compared to women without polymorphism (CI95%:1.065- 32.082; P = 0.03). Multivariate analysis confirmed that the VDR Apa1 polymorphism independently influence and increase the risk of breast cancer without being influenced by other variables (95% CI: 1.065-32.082; P = 0.042).Conclusion: In this study has shown VDR Apa1 polymorphism significantly associated and increased the risk of breast cancer in women in Bali.