Alkylation of the pyridone (I) with the halides (II) gives the N‐substituted pyridones (III) and, from (I) and allyl chloride (IId), the allyloxypyridine (IVd).

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Interest in annelated pyridines is caused by the broad spectrum of their practical application. These compounds are used as medicinal preparations, for example, 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones are known as diuretic agents [1][2][3][4]. Condensed pyridines are also used as plant protection agents [5], and in organic synthesis [6]. The synthesis of 2-substituted 1-phenylpyrido[2,3-d]pyrimidin-4(1H)-ones in low yield by the interaction of 2-(phenylamino)nicotinamides with acetic anhydride is described in the literature [7,8]. The present study is devoted to the development of methods of synthesis of new pyrido[2,3-d]pyrimidin-4(1H)-ones. Scheme 1 N NH CN R Me N NH NH 2 O R Me 1 1 R R 2a-d 1a-d KOH EtOH 1,2 а R = Me, b-d R = MeOCH 2 ; а,b R 1 = PhCH 2 , c R 1 = 4-MeOС 6 Н 4 , d R 1 = 4-FС 6 Н 4