The aim —  to assess the method of adaptation of the oxygenator’s contact surface based on recepient’s blood serum albumin to the patient’s blood cells changes.Materials and methods. On the basis of the Surgical Center of SS «RPC PCM» SAD at the period from November 2016 to March 2017, 42 patients with AAH were operated. Patients were divided into two groups. Patients of the 1st group (30 patients, 24/6 person/women, respectively) were treated with AAH without processing adaptive composition (AdC). For patients of the 2nd group (12 patients — 9/3 patients/women respectively), AdC treatment of oxygenator was performed. The effectiveness of AdC treatment was monitored by a general blood analyzes and red blood cell state.Results and discussion. The use of AdC for treatment contact surface of oxygenator reduces the body’s response to it — a slight increase in WBC, a decrease in % of lymphocytes and granulocyte content in comparison with untreated version. In addition, in these cases, the absence of echinocytes and microcytes indicates adequate oxygen supply of red blood cells.Conclusions. Treatment AdC the contact surface of the oxygenator results in a decrease in the body’s response to it and increases the number of erythrocytes that contact with the gas exchange membrane.