R-FC significantly improved the outcome of patients with previously treated CLL.

Polymorphisms of activating

No abstract

Up to the present time, earth-rock work in hydraulic construction has been carried out with equipment which operates on the basis of a cyclic technical scheme. Construction experience indicates that cyclic technicalschemes for performing earth--rockwork are labor-consuming and call for significant expenditures of resources and time. In recent years, at ferrous and nonferrous metallurgical enterprises, in the coal industry, and at quarries from which construction materiais are extracted, the progressive eyelic-flowline and flowline have been introduced [1][2][3][4][5][6][7][8][9][10][11]. Investigations carried out by several institutes belonging to the mining industry have revealed that the use of cyclieflowline techniques in earth--rock work makes it possible to increase the productivity of labor by a factor of 2 to 3 and to reduce the cost of this work by 20%.In hydraulic construction, the cyclic-flowline and flowline techniques could find application primarily for the construction of embankment dams, especially in the extraction and conveyance of the earth and rock material from the quarries to the dams, for exploitation of gravel--sand and rock quarries to obtain aggregates for concrete, and for constructing canals by placing soils in fills.In the flowline technique, use is made of continuous-action machines, and in the cyclic-flowline technique, a combination of cyclic-and continuous-action machines is used: excavators, loaders, dump trucks, crushers, and belt conveyors or any other types of continuous-transport machines, whichare the main links in the cyclic-flowline technique.The extraction of soft andgravel--sandsoils by cyclic-flowline and flowline techniques can be carried out by means of mass-produced equipment and without any additional technical operations. In the excavation of semirock and rock material, for transport by ordinary belt conveyors it is necessary to crush the rock to a size less than 600 mm, or use should be made of special belt conveyors adequate for transport of rock material over 600 mm in size. These special belt conveyors are being developed at the present time [ii]. The characteristics of conventional belt conveyors are presented in Table 1 [I].

The Mica hydro development (Fig. 1) is being constructed on the Columbia River in Canada, 135 km north of the city of P~velstoke. The hydro development (Fig. 2) is composed of a gravel-earth dam, 244 m high, 823 m long at the crest, 014 m wide at the bass, and fill volume of 32.1 million mS; underground powerhouse (Fig. 3) measuring 213 by 23 m and 49 m high with six units of 333 MW each, total capacity 2000 MW, located on the right bank; water intake for the six units, about 80 m high; left-bank open spillway designed for a maximum discharge of 4250 mS/ssc. Two 13.7-m-diamet~ tunnels, 893 and 1036 m long, designed for a maximum discharge of 4250 mS/see, were provided for on the left bank for passage of discharges during construction. The dam forms a reservoir with a volume of 23 km 3, of which the useful storage is 14.8 km s. Construction of the Mica hydro development for streamflow control and production of electrical energy is being accomplished in accord with an agreement between Canada and the USA. Additional production will be possible by equalizing the stream flow at hydro developments located on the Columbia River in the USA, which will compensate the Canadian side with 250 million dollars. In addition, the sum paid by the USA for flood control amounted to 60 miUion dollars.The transportation system for construction of the hydro development called for delivery of tl~ main freight by railroad to Rcvelstoke and thence by motor transport to the construction site. Cement is delivered from plants in the neighboring province of Alberta by motor transport over a distance of about 500 kin.Construction of the hydro development began in 1964 with development of the construction sits. In that year a temporary residential village for 2500 persons, designed for 10-15 years, was constructed south of the dam site on the bank of the Columbia. The construction administration, dining hall, clubhouse, shopping center, school, hospital, hotel, bank, etc., are located in the village. As a rule the houses are two-story, four-apartment, and of the dormitory type. * Based on materials of an official business trip.