Summary. Persistent polyclonal B-cell lymphocytosis (PPBL) is an unusual and benign lymphoproliferation characterized by a polyclonal expansion of B lymphocytes, whose nature remains undetermined. The phenotypic analysis of three cases revealed that these cells were CD27 sequenced. An average of 73% of these sequences were mutated. The mean number of mutation per sequence was 6AE9, a number similar to those observed in the MZ B-cell compartment.
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