ABSTRACT. A sample of institutionalized, mentally handicapped adults who suffered from epilepsy was compared with a matched control group without epilepsy in order to investigate profiles of adaptive skills and of behavioural disturbance. Results suggested that mentally handicapped people with epilepsy have consistently poorer life skills than their peers with no epilepsy but behavioural disturbance was not significantly elevated, except for a small sub‐group whose epilepsy was resistant to pharmacological control. These results are discussed with reference to past research and management implications are considered.

Chronic administration of cimetidine was found to produce a fall in steady-state plasma concentrations of chlorpromazine and of indomethacin in patients. In each case there was some evidence of inhibition of metabolism, suggesting that the mechanism must therefore be decreased absorption sufficient to over-ride the metabolic change. This was confirmed by measurement of excretion of metabolites in the indomethacin study. The fall in indomethacin plasma concentrations was not associated with a change in the clinical effectiveness of the anti-inflammatory therapy.

The broad spectrum approach to the management of solvent abuse adopted at a clinic held at a police station in the East End of Glasgow, in collaboration with members of the community involvement branch of the police, is described. The results reported in this study concern 300 children betow the age of 16years, who attended the clinic between October 1978 and December 1980. The facets of the study which are of central interest are: the rote of the police, the apparent resolution of the activity, the lack of physical damage, the very low incidence of associated psychiatric disorder, and the increased incidence of solvent use by children of single parent families and in those families where the father is unemployed and in only a minority of cases is there a mixed disturbance of conduct and emotions for which psychiatric intervention is warranted.

TTu broad spectrum approach to the management of solvent abuse adopted at a clinic held at a police station in the East End of Glasgow, in collaboration with members of the community involvement branch of the police, is described. The results reported in this study concern 300 children below the age of 16years, who attended the clinic between October 1978 and December 1980. The facets of the study which are of central interest are: the role of the police, the apparent resolution of the activity, the lack of physical damage, the very low incidence of associated psychiatric disorder, and the increased incidence of solvent use by children of single parent families and in those families where the father is unemployed and in only a minority of cases is there a mixed disturbance of conduct and emotions for which psychiatric intervention is warranted.

SUMMARY Serum enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase (ALP), y-glutamyltransferase, and creatine kinase (CK)) were measured in 296 young persons who admitted to recent inhalation of solvents, usually toluene based glues. In general, results fell within expected adult reference ranges except for ALP and CK. About 60% of subjects had CK activities above the upper reference limit and these activities were investigated in terms of their isoenzyme composition.CK B subunit activity was measured in 90 subjects with raised total CK activities. In five instances the CK B subunit activity was judged abnormal and in two subjects the presence of CK BB was confirmed. These two subjects were thought to have a circulating macro CK, type 1.