Liquefied Petroleum Gas (LPG) plant workers are exposed to a number of hydrocarbons from handling petroleum and petroleum-based products and this exposure poses a major health challenge to these workers. This study was designed to evaluate the effects of duration of exposure on biochemical and haematological profile in LPG plant workers. A total of one hundred (100) subjects between 20-60 years were recruited for this study which consist of fifty (50) liquefied gas plant workers and fifty (50) non LPG gas plant workers. Blood samples (10ml) were collected from the cubital vein of each subject using sterile needles and syringes into K3-EDTA tubes and plain plastic containers. The biochemical and haematological parameters were analyzed using standard procedures as prescribed by the manufacturers. The results showed that there was significance difference (p<0.05) observed in all the heamatological parameters as compared with the respective controls. However, there was no significant difference ((p>0.05) in neutrophils values obtained as compared with the control. The serum sodium levels were higher in subjects that had one year exposure. Serum potassium was higher in the subjects with 2-3 years of exposure. Urea and creatinine levels were higher in subjects with 4-5 years of experience. AST levels were higher in subjects with one year experience when compared with other years. ALT were higher in subject with 2-3 years exposure. ALP levels were higher in subjects with 4-5 years of exposure while GGT levels were higher in subjects with 5 years of exposure. There was no significant difference (p>0.05) observed in the renal and liver profile within the period of exposure to LPG. However, the total white blood cell count was significantly higher (p<0.05) in subjects with 4-5 years and over 5 years of exposure when compared with 1 year and 2-3 years of exposure while there was no significant difference (p<0.05) observed for other haematological parameters. The results of this study showed that exposure to LPG resulted in significant alterations in haematological parameters. However, exposure to LPG had significant effect only on the total white blood cell count while there was with no significant effect on the renal and liver profile of LPG plant workers.