Infectious diseases have always been and remain relevant throughout the entire history of human existence. In particular, in recent years, the number of cases of naturally occurring zooanthroponous diseases the causative agents of which are transmitted mainly through tick bites has increased. The epidemiological situation regarding such an infectious disease as tick-borne encephalitis changes every year. With the gro­wing popularity of tourism, this infection is becoming a problem not only within endemic regions. More and more cases of diseases not related to risk factors of a professional nature are being registered, which attracts attention and requires a review of the attitude to the disease, a deeper study of the features of its pathogenesis, clinical manifestations, methods of diagnosis, treatment, as well as the search and application of the maximum effective prevention methods.