Background:In this study, we used scanning electron microscopy (SEM) and atomic force microscopy (AFM) to examine the changes in morphology of red blood cells (RBCs) and to investigate the nanoparticles (NPs) found on their surface in cervical cancer (CC) patients undergoing radiation therapy (RT).Methods and Results: We obtained smears of venous blood from 12 CC patients at the start, midway and at the end of external beam RT and then midway and at the end of brachytherapy. It was found that in CC patients, the number of RBCs with abnormal morphology increased and NPs appeared on their surface. During RT, the total number of abnormally shaped RBCs and the number and size of NPs increased. The RBC diameter was 8.38±0.36 μm in the control group and 9.41±0.47 μm in CC patients. The average diameter of NPs on the RBC surface was 69.91±12.15 nm and their average height 23.75±3.70 nm. After RT, the morphology of RBCs was restored, and the formation of NPs decreased. Conclusion:The changes observed could serve as the basis for developing efficacy indicators of cancer radiation therapy.

No abstract

The research objective was to study the association of the AGT rs699 missense SNP with arterial hypertension (AH) and metabolic risk factors among indigenous people of the Arctic territory of Yakutia. The obtained data show that representatives of indigenous people of the Arctic territory of Yakutia with the homozygous GG genotype for the AGT SNP rs699 are characterized by high levels of systolic blood pressure. The carriage of the GG genotype in AH patients is associated with a high frequency of hypo-HDL cholesterolemia. The carriage of GG genotype in AH patients, compared to subjects without AH, is characterized by higher blood levels of total cholesterol, LDL-C, and triglycerides and is associated with a high frequency of abdominal obesity. Thus, the AGT rs699 missense SNP was found to be associated with metabolic risk factors in indigenous AH persons of the Arctic territory of Yakutia.

The aim of this study was to assess the anthropometric and physiometric indicators with an analysis of the body composition of young Yakuts of early and late puberty, living in the Republic of Sakha (Yakutia) (RS(Y)). Materials and Methods: A total of 184 indigenous youths aged from 14 to 17 years, permanently residing in RS(Y), were examined. The study used generally accepted methods: anthropometry, dynamometry, spirometry, caliperometry, and body composition assessment by bioelectrical impedance analysis. Results: Among Yakut youth living in RS(Y), an increase in musculoskeletal mass and a decrease in fat mass was observed in groups aged 14 to 17. In the period from 14 to 17 years, Yakut youth show significantly increased indicators of dynamometry, deadlift and vital lung capacity. The data above are accompanied by a decrease in the indicators of the content of fat mass and an increase in lean body mass, musculoskeletal mass and body cell mass. There is growth not only in skeletal muscles and skeleton, but also in the mass of internal organs. The data obtained will be used to develop an interval classification of body composition parameters for males of different ages in order to develop standards of physical development specifically for people living in RS(Y).

Background:The objective of our research was to study the ethnic-related characteristics of lipid and carbohydrate metabolism in the indigenous population of Yakutia.Methods and Results: The study was conducted under expeditionary conditions in the North of Yakutia (Nizhnekolymsky, Anabarsky, Verkhnekolymsky, Tomponsky, and Srednekolymsky districts). In total, 529 people aged between 20 and 70 years were examined in the primary health care units. For a comparative analysis, we formed 6 ethnic groups (Yakuts, Evenks, Evens, Dolgans, Chukchi, Yukagirs). In all ethnic groups, there was a high prevalence of atherogenic dyslipidemia, with the highest frequency in Evenks and Yakuts. Women had a higher frequency of lipid metabolism disorders than men did. The frequency of hyperglycemia was significantly higher among the Dolgans, Evenks and Yakuts than in other ethnic groups.Conclusion: This study showed a high frequency of metabolic syndrome in the examined ethnic groups, which is caused by a change in the traditional lifestyle and the nature of nutrition.