Purpose: to study the correlation between the acoustic and morphometric parameters of the optic nerve (ON) and anthropometric data in healthy young people.Material and methods. The research involved 24 healthy volunteers (48 eyes), including 9 men and 15 women, the average age was 25.0 ± 1.9 years. Anthropometry included measurements of height, weight, and body mass index (BMI). Ultrasound examination of the retrobulbar part of the ON included measurement of the thickness of the ON with and without sheath, echodensitometry of the ON, and ocular biometry. Using optical coherence tomography, we measured the intraocular part of the ON, including the registration of Bruch's membrane opening and ovality index.Results. The average ON thickness with the sheath was 4.6 ± 0.3 mm, and without sheath, 2.6 ± 0.2 mm. In men, ON with the sheath was thicker than in women (p = 0.001). The acoustic density of the parenchyma of the orbital part of ON was 101.2 ± 11.4 r.u. in women, the mean acoustic density of the ON was significantly higher than that in men. Correlation analysis revealed a statistically significant correlation between the height and the thickness of the ON with the sheath (r = 0.480). The strongest reliable correlation was established between the index of the ON thickness and body weight (r = 0.712) and BMI (r = 0.509) (p < 0.05). No statistically significant correlation was found between the morphometric parameters of the optic disc, anthropometry data and acoustic parameters of the ON.Conclusion. Studying the acoustic and morphometric characteristics of the intraocular and intraorbital parts of the ON in healthy young people, which included anthropometric data and gender characteristics, will contribute to the development more accurate diagnostic criteria of ON state evaluations.

We present a brief description of acute retinal necrosis, a rare and severe condition that is accompanied by a rapid development of inflammatory and occlusive events in the retinal vasculature preceding peripheral necrotizing retinitis. Despite successful etiotropic conservative therapy, the disease is complicated by proliferative vitreoretinopathy with a high risk of retinal detachment, leading to irreversible loss of sight. We present a clinical case of acute retinal necrosis in a patient with one seeing eye who experienced a reactivation of herpes simplex virus type 2 infection, discussing the treatment details and result.

Tacrolimus is an effective immunosuppressive agent that is widely used in transplant surgery. Rare complications of its usage include optic neuropathy or maculopathy development. AIM: To present a clinical case of tacrolimus-induced optic neuropathy and retinopathy CLINICAL CASE. A family with a 17-year-old boy was referred to Helmoltz National Medical Research Center of Eye Diseases with complaints of sudden painless decreased vision in his right eye. The best-corrected visual acuity was the right eye of 0.3 and the left eye of 1.0. Ophthalmoscopy of his right eye revealed pigment mottling in the macula and paramacular region, mid-peripheral patchy pigment deposition in 2, 4, and 8 clock meridians. No pathological findings were revealed in his fellow eye. From the anamnesis, 15 years ago, the patient underwent liver transplantation (Alagille syndrome). From the moment of surgery to the date he received tacrolimus. Optical coherence tomography highlighted foveal smoothing, ellipsoid zone and retinal pigment epithelium disruption, macular and paramacular choroid thinning, and neuroretinal rim thickening. Computed microperimetry revealed a significantly decreased sensitivity in the central retinal zone of the right eye. Autofluorescence examination showed multiple punctate hypoautofluorescent spots in the macula and paramacula in the right eye, as well as hyperautofluorescent zones in the posterior pole in both eyes. Electric activity analysis has revealed decreased full-field electroretinogram parameters and P100 amplitude in visually-evoked potentials in the right eye and a decreased a-wave full-field electroretinogram of the left eye. The data provided by the parents suggest that the target tacrolimus concentration in plasma was exceeded 2 times just before the patient noticed vision impairment. Differential diagnoses included infectious and non-infectious posterior uveitis. CONCLUSION: The first case of combined retinopathy and optic neuropathy in adolescents induced by long-term tacrolimus treatment was described.