The present article is concerned with the study of glial fibrillary acidic protein (GFAP) level in the blood serum of pregnant women  with post–trauma brain injury syndrome (post-TBI syndrome) as the marker of  hematoencephalic barrier status and predictor of obstetric and perinatal complications development.

Український журнал медицини, біології та спорту-2020-Том 5, № 4 (26) 201 shortness of breath during physical activity. The decrease in total cholesterol levels was not more than 12% in the lipid spectrum of blood. Conclusion. According to the results of coagulogram, 6 patients showed an increase in the stenting capacity of the blood. The indicated results proved the effectiveness and appropriateness of the appointment of carvellis for the complex treatment of stable angina, as it had good antianginal, hypolipidemic and sedative effects, potentiated the therapeutic effect of most cardiologic drugs, which positively affected the health of patients.

The purpose of the study was to investigate the clinical and prognostic significance of anemia, including iron deficiency, in patients with chronic heart failure. Materials and methods. A retrospective cohort study was conducted among 46 patients of the Poltava Regional Cardiovascular Center of the Poltava Regional Council, who in 2021 were on out-patient and in-patient treatment diagnosed with chronic heart failure of various functional classes. The information was collected by analyzing the data of laboratory examinations of patients during life, which were recorded in their medical records. Results and discussion. Cardiovascular disease is identified as the leading cause of death in people regardless of age and sex worldwide. About half of all hospitalizations each year is the result of cardiovascular disease, including acute myocardial infarction, chronic heart failure, cardiomyopathy, and life-threatening cardiac arrhythmias. Increasing attention is being paid to finding the causes of cardiovascular risk, which also significantly affect the degree of manifestations and progression of certain pathogenetic changes in the human body. Recently, anemia has been increasingly singled out as one of these factors. It is proved that iron deficiency significantly reduces the quality of life, physical activity both in the presence of anemia and in its absence. Recent recommendations from the European Society of Cardiology for Heart Failure recommend that all patients with heart failure be screened for serum ferritin and transferrin, with or without anemia and iron deficiency. However, the question remains – cardiovascular risk factor. It was found that the degree of progression of anemia is directly related to the degree of progression of chronic heart failure. In more than half of the patients, anemia was a predictor of cardiovascular disease. In patients with primary kidney disease, anemia develops in almost all cases and contributes to postoperative complications. The degree of pathogenetic, clinical, diagnostic and therapeutic relationship between these pathological conditions demonstrates that anemia is a marker of subclinical chronic renal failure in patients with heart failure. Thus, anemia is not only a direct factor in cardiovascular risk but also a cause of unfavorable prognosis. Conclusion. Anemia can be identified as one of the risk factors for cardiovascular disease and factors for its progression. There is a direct relationship between functional classification of heart failure and the severity of anemia. All patients with iron deficiency were diagnosed with III-IV functional classification of heart failure. Already at the detection of primary hematological changes that indicate the presence and development of anemia, a comprehensive examination of the patient should be conducted and an appropriate therapy, depending on the genesis of anemia, which will reduce cardiovascular risk in the future, should be initiated

РезюмеЦель работы: изучение уровня астроглиального нейроспецифического белка -глиофибриллярного кислого протеина (GFAP) в сыворотке крови беременных с посткоммоционным синдромом (ПКС) после легкой закрытой черепно-мозговой травмы в качестве маркера состояния гематоэнцефалического барьера (ГЭБ) и предиктора развития акушерских и перинатальных осложнений. Материалы и методы. Для оценки влияния физиологических изменений во время беременности на проницаемость ГЭБ и состояние астроцитов головного мозга иммуноферментным методом исследовали содержание GFAP в сыворотке крови 93 женщин: у 41 беременной с ПКС (основная группа), у 31 соматически здоровой беременной (группа сравнения), у 21 небеременной репродуктивного возраста (группа контроля). Результаты. У здоровых беременных уровень GFAP практически не отличался от его значений у небеременных репродуктивного возраста и не превышал пороговой величины 4,0 нг/мл. У большинства же беременных с ПКС (70,73%) значения GFAP были выше порогового уровня с I триместра и имели тенденцию к повышению в последующем, что свидетельствует об иммунологической сенсибилизации. Заключение. В акушерской и неврологической практике беременным с ПКС рекомендуется исследование GFAP в сыворотке крови иммуноферментным методом в качестве маркера иммунологической сенсибилизации и предиктора осложнений беременности, родов и ухудшения неврологического статуса. Ключевые словаБеременные, посткоммоционный синдром, глиофибриллярный кислый протеин. Статья поступила: 05.09.2017 г.; в доработанном виде: 27.10.2017 г.; принята к печати: 08.12.2017 г. Конфликт интересовАвторы заявляют об отсутствии необходимости раскрытия финансовой поддержки или конфликта интересов в отношении данной публикации.Все авторы сделали эквивалентный вклад в подготовку публикации. Для цитированияСимрок В.В., Цыганенко И.В. Особенности метаболизма глиофибриллярного кислого протеина у беременных с посткоммоционным синдромом. Акушерство, гинекология и репродукция. SummaryThe aim: to evaluate the astroglial neurospecific protein -gliofibrillary acidic protein (GFAP) in the blood serum of pregnant women with post-concussion syndrome (PCS) resulted from a mild closed brain injury. The serum level of GFAP was earlier proposed to be used as a marker of the state of the blood-brain barrier (BBB) and a predictor of obstetric and perinatal complications. Materials and methods. To evaluate the permeability of the BBB and the integrity of astrocytes during pregnancy, we measured GFAP (using the enzyme immunoassay) in the sera of 93 women: 41 with PCS (main group), 31 somatically healthy pregnant women (comparison group), and 21 non-pregnant women of the reproductive age (control group). Results. In healthy pregnant women, the level of GFAP did not significantly differ from that in the non-pregnant women and did not exceed a threshold value of 4.0 ng/ml. In most of the pregnant women with PCS (70.73%), the GFAP values exceeded the threshold level starting from the first trimester and tended to increase subsequently, which was indicative of immunol...