This study examined ways in which people from different occupational backgrounds in South Australia perceived issues relevant to the misuse of substances. Questionnaires were completed by representatives from eight occupational groups, namely, Doctors, Nurses, Ambulance Officers, Social Workers, Youth Workers, Teachers, the Police, and Probation and Parole Officers (in total, N = 276). Significant differences were found between occupational groups in their judgments of the relative incidence of substance misuse in the community, the comparative harmfulness of alcohol and marijuana, the attribution of alcohol misuse to personal inadequacy, and the efficacy of treatment of alcohol misuse.