Pakistan. Methods: A qualitative approach was used. Semi-structured interviews were conducted with 18 practicing physicians and pharmacists of Abbottabad until the emergence of saturation point. All the interviews were transcribed verbatim and thematically analyzed for its content. Results: Among the study participants eleven (11) were physician and seven (7) were pharmacist. The thematic content analysis of the interviews revealed 3 major themes: Familiarity with pharmacovigilance, attitude towards pharmacovigilance and barriers related with ADRs reporting system. In case of familiarity with pharmacovigilance and ADRs reporting, majority of respondents were even unware with the term pharmacovigilance. The assessments of transcripts also revealed that majority of respondents have positive attitude towards Pharmacovigilance or ADRs reporting and they believe that ADR reporting is a part of their professional responsibility. The study identified the major barriers for pharmacovigilance or ADRs reporting to be lack of knowledge to identify type of ADRs, Unavailability of proper pharmacovigilance center in Pakistan, lack of knowledge that how to report ADR and where to report. ConClusions: The majority of respondents surveyed had little knowledge about ADR reporting system. It is emphasized the importance of establishing a pharmacovigilance center in Pakistan and also there is need to train the physician and pharmacist regarding pharmacovigilance.

and outpatient pharmacies in Riyadh City in 2014. The survey gathered information about formulary management and pharmacy operations. Results: Of the 30 hospitals pharmacies, 23(76.6%) pharmacy managers responded, only 21(70%) hospitals pharmacies met the inclusion criteria.Of 21 hospitals, 9(42.9%) hospital pharmacies have Inventory Control System (ICS) that are integrated with prescription processing system which provide alert when the stock supply reach certain level to maintain the drug supply and availability of medications to the patients, on the other hand 7(33.3%) hospital pharmacies did not have ICS.11 (66%) pharmacies provided formulary information update in timely manner, 7(33.3%) pharmacies in annual basis and 3 (14.3) hospital pharmacies did not provide update.Of 21 hospitals, 7(33.3%) hospital pharmacies send drug availability update information to the physicians within the hospital and it's clinics on daily or weekly basis either online or e-mail, while 9(42.8%) send update information in monthly, quarterly or annual basis.Of 6 pharmacy private managers, 5 (83.3) of perceived the drug supply and availability of medication for their patients as good and very good. ConClusions: Drug availability for patient use in Saudi hospitals depends on the supply chain, distribution system, and also on the flow of information in timely manner between the pharmacy and the physicians. The pharmacy mangers in private hospitals are more likely to be satisfied with drug supply and patients' accessibility to prescription drugs comparing to governmental pharmacy mangers , non formulary restriction and non-centralized supply distribution system might be the explanation for the high satisfaction level for the private pharmacy mangers. PHS105 ImPact of State mandated QuerIeS of tHe PreScrIPtIon drug monItorIng ProgramS on oPIoId and non-oPIoId drug related adverSe effectS: a dIfference In dIfference aPProacH

A 3 4 7 -A 7 6 6 A679 the results of the literature review and interviews, a draft item pool was developed and refined through two rounds of cognitive debriefing interviews with 6 additional patients (3 per round). Results: HPTH symptoms documented in the literature included muscle cramping/pain, tingling in limbs and extremities, muscle spasms, fatigue, joint/bone pain, heaviness/weakness in extremities, sleep disturbances, cognition issues, anxiety/fear, and sadness/depression. However, PRO measures appropriate to address these symptoms were not identified. Qualitative research participants included 11 females and 1 male with an average age of 49 years; the majority (10) of these participants were white. CE interview results were generally consistent with the results of the literature review; the most commonly reported symptoms included issues with cognition, often described as "brain fog" (n = 6), muscle cramping (n = 5), tingling (n = 5), and muscle spasms or twitching (n = 4). A total of 13 items comprise the HPTH Symptom Diary, which was found to be easily understood and relevant to the participants. ConClusions: The HPTH Symptom Diary addresses the symptoms of HPTH important to patients. Further research is planned to develop a scoring algorithm and evaluate the measure's psychometric properties.

chart review study of patients aged 1-12 years with a primary varicella diagnosis between 2011 and 2015. Healthcare resource utilization (HCRU) associated with varicella, unit costs, and work loss were used to estimate direct and indirect costs. All costs are presented in 2015 Polish Zloty (PLN) / Euros (€ ). Results: 150 children with varicella were included (75 outpatients, 75 inpatients), with a mean age of 3.9 (SD: 2.6) and 4.2 (SD: 2.3) years, respectively. One or more complications were experienced by 14.7% of outpatients and 82.7% of inpatients, the most common being skin and soft tissue infections, dehydration, pneumonia, and cerebellitis. HCRU estimates included use of over-the-counter (OTC) medications (80.0% outpatients, 81.3% inpatients), prescription medications (80.0% outpatients, 93.3% inpatients), tests/procedures (0.0% outpatients, 69.3% inpatients), and consultation with allied health professionals (0.0% outpatients, 24.0% inpatients). The average duration of hospital stay was 4.7 (95% CI: 4.1 , 5.3) days for inpatients. The total combined direct and indirect cost per varicella case was 5013.3 PLN / € 1,198.1, for inpatients and 1027.2 PLN/ € 245.5, for outpatients. The overall annual cost of varicella in Poland for children aged 1-15 years in 2015 was estimated at 177,655,759.6 PLN,/€ 42,458,716.0. ConClusions: Varicella is associated with substantial clinical burden in Poland, resulting in the utilization of a significant amount of healthcare resources.

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