This paper examines the relationship between inflation and economic growth in Ghana. Using quarterly data from 1986Q1 to 2012Q4. The study employs Co-integration and error correction model. The study reveals that capital, government expenditure, labour force and money supply have a positive impact on GDP. In addition, inflation and interest rate has a decreasing impact on economic growth. The study recommends inflation targeting as best monetary policy. There is the need for government to increase expenditure in the area of infrastructure development and human capital to increase output.