One of the major goals of managing the medication of any clinical trial is to ensure that it is distributed effectively. The continued and increasing use of interactive voice response systems (IVRS) in the management of medication has no doubt resulted in savings in terms of optimizing the supply chain. However, as studies become more complex and drug development becomes increasingly expensive, the traditional IVRS system of medication management has had to evolve in response to these increasing demands. As a result, novel methods of IVRS medication management have been developed to provide more flexibility and robustness in the strategies used to manage medication in a bid to further optimize the efficiency of the supply chain.