Atomistic simulations of protein folding have the potential to be a great complement to experimental studies, but have been severely limited by the time scales accessible with current computer hardware and algorithms. By employing a worldwide distributed computing network of tens of thousands of PCs and algorithms designed to efficiently utilize this new many-processor, highly heterogeneous, loosely coupled distributed computing paradigm, we have been able to simulate hundreds of microseconds of atomistic molecular dynamics. This has allowed us to directly simulate the folding mechanism and to accurately predict the folding rate of several fast-folding proteins and polymers, including a nonbiological helix, polypeptide alpha-helices, a beta-hairpin, and a three-helix bundle protein from the villin headpiece. Our results demonstrate that one can reach the time scales needed to simulate fast folding using distributed computing, and that potential sets used to describe interatomic interactions are sufficiently accurate to reach the folded state with experimentally validated rates, at least for small proteins.

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Cardiovascular responses to mental stress tests have been related to future blood pressure (BP) levels. However, most studies have been completed in North America and Europe; only one study has been conducted in Asia. Therefore, the study explored whether cardiovascular responses to mental stress predict future resting BP in Thailand. Hemodynamic measures were obtained from 101 healthy adults before, during and after mental arithmetic, a speech task, and a cold pressor task. A follow-up assessment of resting BP was undertaken 1 year later. Results showed that Thais responded to standardized mental stress tasks with large and significant cardiovascular reactivity. Regression analyses indicated that, after adjustment for baseline BP and traditional risk factors, heightened systolic blood pressure (SBP) responses to mental arithmetic were associated with increased future SBP (ΔR 2 = .045). These findings suggest that BP reactivity predicts future BP and may play a role in the development of hypertension. In addition, Thais displayed large cardiovascular responses to standardized mental stress tasks, of a similar magnitude to previous studies of North Americans and Europeans.

The aim of the study was to establish a new typology of belief in the supernatural; categorising people, based on their levels of religiosity, spirituality and paranormal belief. Examining how the various beliefs are defined was a further objective. The reasons for people having different levels of these beliefs were discussed, highlighting ‘Metaphysical Chauvinism’ as a possible explanation. Previous research that used variousmethods to measure religiosity, spirituality and paranormal belief were discussed. Participants (n = 307) completed an online survey consisting of the revised Religious Life Inventory (rRLI), the Intrinsic Spirituality Scale (ISS) and the revised Paranormal Belief Scale (rPBS). Two cluster analyses were performed: one on the three main scales and a secondary analysis on the ISS, the subscales of the rRLI and the rPBS. The results revealed a four cluster solution for each analysis. For the main analysis the clusters were ‘believers’, ‘paranormal believers’, ‘sceptics’ and ‘religious believers’. Metaphysical Chauvinism was supported; however, it was acknowledged that there still appears to be a lack of consensus when defining supernatural beliefs. It is proposed that the cluster analysis approach is more effective than a simple scale when trying establish how a person believes